ENSMUSG00000020189


Mus musculus

Features
Gene ID: ENSMUSG00000020189
  
Biological name :Osbpl8
  
Synonyms : B9EJ86 / Osbpl8 / Oxysterol-binding protein-related protein 8
  
Possible biological names infered from orthology : oxysterol binding protein like 8 / Q9BZF1
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D1
Gene start: 111164752
Gene end: 111297249
  
Corresponding Affymetrix probe sets: 10366310 (MoGene1.0st)   1437069_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000100911
Ensembl peptide - ENSMUSP00000092948
NCBI entrez gene - 237542     See in Manteia.
MGI - MGI:2443807
RefSeq - XM_006513639
RefSeq - NM_001003717
RefSeq - NM_175489
RefSeq - XM_006513637
RefSeq - XM_006513638
RefSeq Peptide - NP_780698
RefSeq Peptide - NP_001003717
swissprot - B9EJ86
swissprot - A0A0R4J150
Ensembl - ENSMUSG00000020189
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 OSBPL8ENSDARG00000039724Danio rerio
 OSBPL8ENSGALG00000010246Gallus gallus
 OSBPL8ENSG00000091039Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Osbpl5 / Q9ER64 / oxysterol binding protein-like 5 / Q9H0X9*ENSMUSG0000003760653
A2A8Z1 / Osbpl9 / Oxysterol-binding protein-related protein 9 / Q96SU4* / oxysterol binding protein like 9*ENSMUSG0000002855920
Osbpl11 / oxysterol binding protein like 11 / Q9BXB4*ENSMUSG0000002280720
S4R1M9 / Osbpl10 / Oxysterol-binding protein-related protein 10 / Q9BXB5* / oxysterol binding protein like 10*ENSMUSG0000004087520


Protein motifs (from Interpro)
Interpro ID Name
 IPR000648  Oxysterol-binding protein
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR018494  Oxysterol-binding protein, conserved site
 IPR037239  Oxysterol-binding protein superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0010891 negative regulation of sequestering of triglyceride IEA
 biological_processGO:0015914 phospholipid transport IEA
 biological_processGO:0030336 negative regulation of cell migration IMP
 biological_processGO:0032148 activation of protein kinase B activity IMP
 biological_processGO:0045444 fat cell differentiation IEA
 biological_processGO:0046628 positive regulation of insulin receptor signaling pathway IMP
 biological_processGO:0051897 positive regulation of protein kinase B signaling IMP
 biological_processGO:0090204 protein localization to nuclear pore IMP
 biological_processGO:2001275 positive regulation of glucose import in response to insulin stimulus IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0032541 cortical endoplasmic reticulum ISO
 molecular_functionGO:0001786 phosphatidylserine binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005548 phospholipid transporter activity IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0015485 cholesterol binding IEA
 molecular_functionGO:0070273 phosphatidylinositol-4-phosphate binding IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodelling of PS


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Foxp3-EGFP/cre)1cJbs/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * NOD * SJL

 MP:0003980 increased circulating phospholipid level "greater concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Foxp3-EGFP/cre)1cJbs/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * NOD * SJL

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Foxp3-EGFP/cre)1cJbs/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * NOD * SJL

 MP:0010332 abnormal circulating apolipoprotein level "anomaly in the amount in the blood of a protein that is frequently a component of a lipoprotein complex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Foxp3-EGFP/cre)1cJbs/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * NOD * SJL

 MP:0010333 abnormal circulating apolipoprotein E level "anomaly in the amount in the blood of a protein that is frequently a component of a VLDL, HDL, and chylomicron complexes, and functions in cholesterol transport" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Foxp3-EGFP/cre)1cJbs/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * NOD * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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