ENSMUSG00000020260


Mus musculus

Features
Gene ID: ENSMUSG00000020260
  
Biological name :Pofut2
  
Synonyms : Pofut2 / protein O-fucosyltransferase 2 / Q8VHI3
  
Possible biological names infered from orthology : Q9Y2G5
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 77259218
Gene end: 77269575
  
Corresponding Affymetrix probe sets: 10364251 (MoGene1.0st)   1416573_at (Mouse Genome 430 2.0 Array)   1435056_x_at (Mouse Genome 430 2.0 Array)   1437845_x_at (Mouse Genome 430 2.0 Array)   1448384_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020493
Ensembl peptide - ENSMUSP00000151877
Ensembl peptide - ENSMUSP00000151864
Ensembl peptide - ENSMUSP00000151264
NCBI entrez gene - 80294     See in Manteia.
MGI - MGI:1916863
RefSeq - NM_030262
RefSeq Peptide - NP_084538
swissprot - A0A1W2P6H4
swissprot - B2RV73
swissprot - Q8VHI3
swissprot - A0A1W2P844
swissprot - A0A1W2P7Z1
Ensembl - ENSMUSG00000020260
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pofut2ENSDARG00000045175Danio rerio
 POFUT2ENSGALG00000006141Gallus gallus
 POFUT2ENSG00000186866Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR019378  GDP-fucose protein O-fucosyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001707 mesoderm formation IMP
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006004 fucose metabolic process IEA
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010717 regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0036065 fucosylation IMP
 biological_processGO:0036066 protein O-linked fucosylation ISO
 biological_processGO:0051046 regulation of secretion ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 molecular_functionGO:0008417 fucosyltransferase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0046922 peptide-O-fucosyltransferase activity ISO


Pathways (from Reactome)
Pathway description
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: S1pr2tm1Ytak/S1pr2tm1Ytak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: S1pr2tm1Ytak/S1pr2tm1Ytak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
Show

Allelic Composition: Gt(ROSA)26Sortm2(ATF4)Myz/Gt(ROSA)26Sortm2(ATF4)Myz,Tg(Myh11-cre/ERT2)1Soff/?
Genetic Background: either: D2.Cg-Atf4tm1.1Cmad Tg(Myh11-cre/ERT2)1Soff or B6.Cg-Atf4tm1.1Cmad Tg(Myh11-cre/ERT2)1Soff

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm2(ATF4)Myz/Gt(ROSA)26Sortm2(ATF4)Myz,Tg(Myh11-cre/ERT2)1Soff/?
Genetic Background: either: D2.Cg-Atf4tm1.1Cmad Tg(Myh11-cre/ERT2)1Soff or B6.Cg-Atf4tm1.1Cmad Tg(Myh11-cre/ERT2)1Soff

 MP:0002582 disorganized extraembryonic tissue "a lack of the regular arrangement of the membranes involved with the embryo s protection and nutrition" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: S1pr2tm1Ytak/S1pr2tm1Ytak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

 MP:0003543 abnormal vascular endothelial cell differentiation "anomaly in the process whereby a relatively unspecialized cell acquires specialized features of an endothelial cell" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95387]
Show

Allelic Composition: S1pr2tm1Ytak/S1pr2tm1Ytak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: S1pr2tm1Ytak/S1pr2tm1Ytak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003954 abnormal Reichert s membrane "aberrant structure of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm beginning at E6.0 and is secreted by the distal endoderm; required for the maternofetal exchange of nutrients and is important for the postgastrulation development" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: S1pr2tm1Ytak/S1pr2tm1Ytak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003988 disorganized embryonic tissue "a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]
Show

Allelic Composition: S1pr2tm1Ytak/S1pr2tm1Ytak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

 MP:0004229 abnormal embryonic erythropoiesis "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: S1pr2tm1Ytak/S1pr2tm1Ytak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008533 abnormal anterior visceral endoderm "any structural anomaly of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [PMID:17078044]
Show

Allelic Composition: S1pr2tm1Ytak/S1pr2tm1Ytak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Podxltm1Kmn/Podxl+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlsHsd * C57BL/6)

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: S1pr2tm1Ytak/S1pr2tm1Ytak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009331 absent primitive node "absence of the regional thickening of cells at the rostral tip of the vertebrate primitive streak through which gastrulating cells migrate anteriorally to form tissues in the future head and neck; this region organizes the formation of the three embryonic layers and establishes the longitudinal axis and the polarity of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: S1pr2tm1Ytak/S1pr2tm1Ytak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010736 abnormal extraembryonic ectoderm morphology "any structural anomaly of the layer of the ectoderm of the extraembryonic tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: S1pr2tm1Ytak/S1pr2tm1Ytak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Pofut2Gt(OST231463)Lex/Pofut2Gt(RST434)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: S1pr2tm1Ytak/S1pr2tm1Ytak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
Show

Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

 MP:0014134 abnormal embryo morphology "any structural anomaly of an embryo " [MGI:csmith]
Show

Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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