ENSMUSG00000020310


Mus musculus

Features
Gene ID: ENSMUSG00000020310
  
Biological name :Madcam1
  
Synonyms : Madcam1 / Mus musculus mucosal vascular addressin cell adhesion molecule 1 (Madcam1), transcript variant 2, mRNA. / Q61826
  
Possible biological names infered from orthology : mucosal vascular addressin cell adhesion molecule 1 / Q13477
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 79664559
Gene end: 79668537
  
Corresponding Affymetrix probe sets: 10364444 (MoGene1.0st)   1425253_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020554
Ensembl peptide - ENSMUSP00000151928
NCBI entrez gene - 17123     See in Manteia.
MGI - MGI:103579
RefSeq - XM_006513293
RefSeq - NM_001358785
RefSeq - NM_013591
RefSeq Peptide - NP_001345714
RefSeq Peptide - NP_038619
swissprot - Q3U1B3
swissprot - Q61826
swissprot - G5E838
Ensembl - ENSMUSG00000020310
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000028341Gallus gallus
 Q13477ENSG00000099866Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR013783  Immunoglobulin-like fold
 IPR015169  Adhesion molecule, immunoglobulin-like
 IPR036179  Immunoglobulin-like domain superfamily
 IPR037413  Mucosal addressin cell adhesion molecule 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002687 positive regulation of leukocyte migration IBA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IBA
 biological_processGO:0007568 aging IEA
 biological_processGO:0030216 keratinocyte differentiation IMP
 biological_processGO:0034113 heterotypic cell-cell adhesion IBA
 biological_processGO:0050900 leukocyte migration IMP
 biological_processGO:0050901 leukocyte tethering or rolling IBA
 biological_processGO:2000403 positive regulation of lymphocyte migration IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0098640 integrin binding involved in cell-matrix adhesion IBA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Integrin cell surface interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Pdgfratm11(EGFP)Sor/Pdgfra+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * MF1

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Pdgfratm11(EGFP)Sor/Pdgfra+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * MF1

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Pdgfratm11(EGFP)Sor/Pdgfra+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * MF1

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Pdgfratm11(EGFP)Sor/Pdgfra+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * MF1

 MP:0008098 decreased plasma cell number "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Pdgfratm11(EGFP)Sor/Pdgfra+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * MF1

 MP:0008135 small Peyer s patches "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
Show

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Pdgfratm11(EGFP)Sor/Pdgfra+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * MF1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001281 Itgb7 / P26011 / Integrin beta-7 / P26010* / integrin subunit beta 7*  / complex / reaction
 ENSMUSG00000026581 Sell / P18337 / selectin, lymphocyte / P14151* / selectin L*  / reaction / complex
 ENSMUSG00000020310 Q61826 / Madcam1 / Mus musculus mucosal vascular addressin cell adhesion molecule 1 (Madcam1), transcript variant 2, mRNA. / Q13477* / mucosal vascular addressin cell adhesion molecule 1*  / reaction / complex
 ENSMUSG00000027009 Itga4 / integrin subunit alpha 4 / P13612*  / complex / reaction






 

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