ENSMUSG00000020407


Mus musculus

Features
Gene ID: ENSMUSG00000020407
  
Biological name :Upp1
  
Synonyms : P52624 / Upp1 / uridine phosphorylase 1
  
Possible biological names infered from orthology : Q16831
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A1
Gene start: 9118103
Gene end: 9136170
  
Corresponding Affymetrix probe sets: 10374236 (MoGene1.0st)   1448562_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127473
Ensembl peptide - ENSMUSP00000129276
Ensembl peptide - ENSMUSP00000129787
Ensembl peptide - ENSMUSP00000020677
Ensembl peptide - ENSMUSP00000099063
Ensembl peptide - ENSMUSP00000123285
Ensembl peptide - ENSMUSP00000125934
NCBI entrez gene - 22271     See in Manteia.
MGI - MGI:1097668
RefSeq - NM_001159402
RefSeq - XM_006514667
RefSeq - NM_009477
RefSeq - NM_001159401
RefSeq Peptide - NP_001152873
RefSeq Peptide - NP_001152874
RefSeq Peptide - NP_033503
swissprot - Q5SUC8
swissprot - F6YBT6
swissprot - P52624
swissprot - Q5SUC6
swissprot - E9Q391
swissprot - E9Q5K7
Ensembl - ENSMUSG00000020407
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 upp1ENSDARG00000040869Danio rerio
 UPP1ENSGALG00000013073Gallus gallus
 UPP1ENSG00000183696Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Upp2 / Q8CGR7 / uridine phosphorylase 2 / O95045*ENSMUSG0000002683960


Protein motifs (from Interpro)
Interpro ID Name
 IPR000845  Nucleoside phosphorylase domain
 IPR010059  Uridine phosphorylase, eukaryotic
 IPR018016  Nucleoside phosphorylase, conserved site
 IPR035994  Nucleoside phosphorylase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006218 uridine catabolic process IDA
 biological_processGO:0006220 pyrimidine nucleotide metabolic process IMP
 biological_processGO:0009116 nucleoside metabolic process IEA
 biological_processGO:0009166 nucleotide catabolic process IEA
 biological_processGO:0042149 cellular response to glucose starvation IEA
 biological_processGO:0044206 UMP salvage IEA
 biological_processGO:0046108 uridine metabolic process IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004850 uridine phosphorylase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0016763 transferase activity, transferring pentosyl groups IEA


Pathways (from Reactome)
Pathway description
Pyrimidine salvage
Pyrimidine catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tymptm1Mihi/Tymptm1Mihi
Genetic Background: B6.129X1-Tymptm1Mihi

 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Upp1tm1Akiy/Upp1tm1Akiy
Genetic Background: Not Specified

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Upp1tm1Akiy/Upp1tm1Akiy
Genetic Background: Not Specified

 MP:0003806 abnormal nucleotide metabolism "impaired regulation of nucleotide levels in either production or breakdown of these structural components of nucleic acids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mitfmi-enu122/Mitf+
Genetic Background: involves: 102 * C3H

Allelic Composition: Upp1tm1Akiy/Upp1tm1Akiy
Genetic Background: Not Specified

Allelic Composition: Tymptm1Akiy/Tymptm1Akiy,Upp1tm1Akiy/Upp1tm1Akiy
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Tymptm1Mihi/Tymptm1Mihi,Upp1tm1Gp/Upp1tm1Gp
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tymptm1Akiy/Tymptm1Akiy,Upp1tm1Akiy/Upp1tm1Akiy
Genetic Background: involves: 129X1/SvJ

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mitfmi-enu122/Mitf+
Genetic Background: involves: 102 * C3H

Allelic Composition: Upp1tm1Akiy/Upp1tm1Akiy
Genetic Background: Not Specified

Allelic Composition: Tymptm1Akiy/Tymptm1Akiy,Upp1tm1Akiy/Upp1tm1Akiy
Genetic Background: involves: 129X1/SvJ

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mitfmi-enu122/Mitf+
Genetic Background: involves: 102 * C3H

Allelic Composition: Tymptm1Mihi/Tymptm1Mihi,Upp1tm1Gp/Upp1tm1Gp
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0006007 abnormal basal ganglion morphology "malformation or absence of any of a group of nuclei associated with the ability to carry out willed movements, including the caudate, putamen, nucleus accumbens, globus pallidus, substantia nigra, and subthalamic nucleus" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tymptm1Mihi/Tymptm1Mihi,Upp1tm1Gp/Upp1tm1Gp
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tymptm1Mihi/Tymptm1Mihi,Upp1tm1Gp/Upp1tm1Gp
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0008025 brain vacuoles "the abnormal presence of cavities or fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tymptm1Mihi/Tymptm1Mihi,Upp1tm1Gp/Upp1tm1Gp
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tymptm1Mihi/Tymptm1Mihi,Upp1tm1Gp/Upp1tm1Gp
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mitfmi-enu122/Mitf+
Genetic Background: involves: 102 * C3H

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mitfmi-enu122/Mitf+
Genetic Background: involves: 102 * C3H

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mitfmi-enu122/Mitf+
Genetic Background: involves: 102 * C3H

 MP:0009980 abnormal cerebellum dentate nucleus morphology "any structural anomaly of the largest and most lateral of the deep cerebellum nuclei; it receives axons of Purkinje cells in the lateral cerebellar hemisphere (neocerebellum) and receives its afferents from the premotor cortex and the supplementary motor cortex through the pontocerebellar system, and its efferents project through the superior cerebellar peduncle and is a major source of its fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Tymptm1Mihi/Tymptm1Mihi,Upp1tm1Gp/Upp1tm1Gp
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0010956 abnormal mitochondrial ATP synthesis coupled electron transport "anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tymptm1Mihi/Tymptm1Mihi,Upp1tm1Gp/Upp1tm1Gp
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0011477 abnormal urine nucleoside level "any change in the urinary level of glycosylamines consisting of a nucleobase bound to a ribose or deoxyribose sugar via a beta-glycosidic linkage, including cytidine, uridine, adenosine, guanosine, thymidine and inosine and deoxynucleosides" [MGI:csmith]
Show

Allelic Composition: Mitfmi-enu122/Mitf+
Genetic Background: involves: 102 * C3H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020407 Upp1 / P52624 / uridine phosphorylase 1 / Q16831*  / complex






 

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