ENSMUSG00000020464


Mus musculus

Features
Gene ID: ENSMUSG00000020464
  
Biological name :Pnpt1
  
Synonyms : Pnpt1 / Polyribonucleotide nucleotidyltransferase 1, mitochondrial / Q8K1R3
  
Possible biological names infered from orthology : polyribonucleotide nucleotidyltransferase 1 / Q8TCS8
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A3.3
Gene start: 29130744
Gene end: 29161828
  
Corresponding Affymetrix probe sets: 10374793 (MoGene1.0st)   1444288_at (Mouse Genome 430 2.0 Array)   1452676_a_at (Mouse Genome 430 2.0 Array)   1452677_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020756
NCBI entrez gene - 71701     See in Manteia.
MGI - MGI:1918951
RefSeq - XM_011243751
RefSeq - NM_027869
RefSeq - XM_006514813
RefSeq Peptide - NP_082145
swissprot - Q8K1R3
Ensembl - ENSMUSG00000020464
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PNPT1ENSGALG00000043545Gallus gallus
 PNPT1ENSG00000138035Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001247  Exoribonuclease, phosphorolytic domain 1
 IPR003029  S1 domain
 IPR004087  K Homology domain
 IPR004088  K Homology domain, type 1
 IPR012162  Polyribonucleotide nucleotidyltransferase
 IPR012340  Nucleic acid-binding, OB-fold
 IPR015847  Exoribonuclease, phosphorolytic domain 2
 IPR015848  Polyribonucleotide nucleotidyltransferase, RNA-binding domain
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR022967  RNA-binding domain, S1
 IPR027408  PNPase/RNase PH domain superfamily
 IPR036345  Exoribonuclease, PH domain 2 superfamily
 IPR036456  Polyribonucleotide nucleotidyltransferase, RNA-binding domain superfamily
 IPR036612  K Homology domain, type 1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000957 mitochondrial RNA catabolic process IEA
 biological_processGO:0000958 mitochondrial mRNA catabolic process IEA
 biological_processGO:0000962 positive regulation of mitochondrial RNA catabolic process IEA
 biological_processGO:0000964 mitochondrial RNA 5"-end processing IEA
 biological_processGO:0000965 mitochondrial RNA 3"-end processing IEA
 biological_processGO:0006396 RNA processing IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006401 RNA catabolic process IEA
 biological_processGO:0006402 mRNA catabolic process ISS
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0035458 cellular response to interferon-beta IEA
 biological_processGO:0035927 RNA import into mitochondrion IEA
 biological_processGO:0035928 rRNA import into mitochondrion IEA
 biological_processGO:0043457 regulation of cellular respiration IMP
 biological_processGO:0043631 RNA polyadenylation IEA
 biological_processGO:0045926 negative regulation of growth IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0060416 response to growth hormone IEA
 biological_processGO:0061014 positive regulation of mRNA catabolic process IEA
 biological_processGO:0070207 protein homotrimerization IEA
 biological_processGO:0070584 mitochondrion morphogenesis IMP
 biological_processGO:0071042 nuclear polyadenylation-dependent mRNA catabolic process IEA
 biological_processGO:0071850 mitotic cell cycle arrest IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 biological_processGO:0097222 mitochondrial mRNA polyadenylation IEA
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:2000627 positive regulation of miRNA catabolic process IEA
 biological_processGO:2000772 regulation of cellular senescence IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005758 mitochondrial intermembrane space ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0042788 polysomal ribosome IEA
 cellular_componentGO:0045025 mitochondrial degradosome IEA
 molecular_functionGO:0000175 3"-5"-exoribonuclease activity IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0004654 polyribonucleotide nucleotidyltransferase activity ISO
 molecular_functionGO:0008266 poly(U) RNA binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0034046 poly(G) binding IEA
 molecular_functionGO:0035198 miRNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Actg1tm1Erv/Actg1tm1.1Erv
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0005298 abnormal clavicle morphology "malformation of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Actg1tm1Erv/Actg1tm1.1Erv
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pnpt1tm1.1Teit/Pnpt1tm1.1Teit
Genetic Background: involves: C57BL/6

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pnpt1tm1.1Teit/Pnpt1tm1.1Teit
Genetic Background: involves: C57BL/6

 MP:0010956 abnormal mitochondrial ATP synthesis coupled electron transport "anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Actg1tm1Erv/Actg1tm1.1Erv
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011635 abnormal mitochondrial crista morphology "Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061]
Show

Allelic Composition: Pnpt1tm1Teit/Pnpt1tm1Teit,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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