ENSMUSG00000020641


Mus musculus

Features
Gene ID: ENSMUSG00000020641
  
Biological name :Rsad2
  
Synonyms : Q8CBB9 / Radical S-adenosyl methionine domain-containing protein 2 / Rsad2
  
Possible biological names infered from orthology : Q8WXG1 / radical S-adenosyl methionine domain containing 2
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: A2
Gene start: 26442746
Gene end: 26456452
  
Corresponding Affymetrix probe sets: 10399710 (MoGene1.0st)   1421008_at (Mouse Genome 430 2.0 Array)   1421009_at (Mouse Genome 430 2.0 Array)   1436058_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121791
Ensembl peptide - ENSMUSP00000020970
NCBI entrez gene - 58185     See in Manteia.
MGI - MGI:1929628
RefSeq - NM_021384
RefSeq Peptide - NP_067359
swissprot - D6RJ49
swissprot - Q8CBB9
Ensembl - ENSMUSG00000020641
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rsad2ENSDARG00000004952Danio rerio
 RSAD2ENSGALG00000016400Gallus gallus
 RSAD2ENSG00000134321Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006638  Elp3/MiaB/NifB
 IPR007197  Radical SAM
 IPR013785  Aldolase-type TIM barrel
 IPR026372  Antiviral radical SAM protein viperin
 IPR034395  SPASM/twitch domain-containing


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0034157 positive regulation of toll-like receptor 7 signaling pathway IMP
 biological_processGO:0034165 positive regulation of toll-like receptor 9 signaling pathway IMP
 biological_processGO:0035710 CD4-positive, alpha-beta T cell activation IMP
 biological_processGO:0043367 CD4-positive, alpha-beta T cell differentiation IMP
 biological_processGO:0045071 negative regulation of viral genome replication IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050709 negative regulation of protein secretion IEA
 biological_processGO:0051607 defense response to virus ISO
 biological_processGO:2000553 positive regulation of T-helper 2 cell cytokine production IMP
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0005811 lipid droplet IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043621 protein self-association IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008092 abnormal T-helper 2 cell differentiation "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: a/a,U/U
Genetic Background: Not Specified

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: a/a,U/U
Genetic Background: Not Specified

 MP:0008563 decreased interferon-alpha secretion "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Lrp1tm2Her/Lrp1tm2Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008565 decreased interferon-beta secretion "reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Lrp1tm2Her/Lrp1tm2Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: a/a,U/U
Genetic Background: Not Specified

 MP:0008574 decreased circulating interferon-alpha level "reduction in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Lrp1tm2Her/Lrp1tm2Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008673 decreased interleukin-13 secretion "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: a/a,U/U
Genetic Background: Not Specified

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: a/a,U/U
Genetic Background: Not Specified

 MP:0008703 decreased interleukin-5 secretion "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: a/a,U/U
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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