ENSMUSG00000020718


Mus musculus

Features
Gene ID: ENSMUSG00000020718
  
Biological name :Polg2
  
Synonyms : Polg2 / polymerase (DNA directed), gamma 2, accessory subunit / Q9QZM2
  
Possible biological names infered from orthology : DNA polymerase gamma 2, accessory subunit / Q9UHN1
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E1
Gene start: 106768253
Gene end: 106779537
  
Corresponding Affymetrix probe sets: 10392241 (MoGene1.0st)   1450816_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021060
Ensembl peptide - ENSMUSP00000117441
Ensembl peptide - ENSMUSP00000118975
Ensembl peptide - ENSMUSP00000122755
Ensembl peptide - ENSMUSP00000116583
NCBI entrez gene - 50776     See in Manteia.
MGI - MGI:1354947
RefSeq - XM_006533676
RefSeq - NM_001353435
RefSeq - NM_015810
RefSeq Peptide - NP_001340364
RefSeq Peptide - NP_056625
swissprot - Q9QZM2
swissprot - D6REU1
swissprot - F2Z482
swissprot - D6RFU3
Ensembl - ENSMUSG00000020718
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 polg2ENSDARG00000074933Danio rerio
 POLG2ENSGALG00000003520Gallus gallus
 POLG2ENSG00000256525Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004154  Anticodon-binding
 IPR027030  DNA polymerase subunit gamma-2, mitochondrial
 IPR027031  Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2
 IPR033731  Glycyl-tRNA synthetase-like core domain
 IPR036621  Anticodon-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0022904 respiratory electron transport chain IMP
 biological_processGO:0032042 mitochondrial DNA metabolic process IMP
 biological_processGO:0070150 mitochondrial glycyl-tRNA aminoacylation IBA
 biological_processGO:0070584 mitochondrion morphogenesis IMP
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0042645 mitochondrial nucleoid IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity ISS
 molecular_functionGO:0004820 glycine-tRNA ligase activity IBA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd4tm1.1Tich/Cd4+,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd4tm1.1Tich/Cd4+,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd4tm1.1Tich/Cd4+,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
Show

Allelic Composition: Cd4tm1.1Tich/Cd4+,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Cd4tm1.1Tich/Cd4+,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0011636 disorganized mitochondrial cristae "derangement of the pattern of the inward folds of the mitochondrial inner membrane" [MGI:csmith]
Show

Allelic Composition: Cd4tm1.1Tich/Cd4+,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0011639 decreased mitochondrial DNA content "less than expected amount of DNA contained within the mirochondria of a eukaryotic cell" [MGI:csmith]
Show

Allelic Composition: Cd4tm1.1Tich/Cd4+,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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