ENSMUSG00000020741


Mus musculus

Features
Gene ID: ENSMUSG00000020741
  
Biological name :Cluh
  
Synonyms : Cluh / clustered mitochondria homolog
  
Possible biological names infered from orthology : O75153
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 74649495
Gene end: 74670847
  
Corresponding Affymetrix probe sets: 10378453 (MoGene1.0st)   1428106_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000090593
Ensembl peptide - ENSMUSP00000113371
NCBI entrez gene - 74148     See in Manteia.
MGI - MGI:1921398
RefSeq - NM_001081158
RefSeq - XM_006534353
RefSeq - XM_006534354
RefSeq - XM_017314805
RefSeq Peptide - NP_001074627
swissprot - A0A0R4J140
swissprot - Z4YLI8
Ensembl - ENSMUSG00000020741
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cluhaENSDARG00000030913Danio rerio
 cluhbENSDARG00000060566Danio rerio
 CLUHENSGALG00000005854Gallus gallus
 CLUHENSG00000132361Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR023231  GSKIP domain superfamily
 IPR025697  CLU domain
 IPR027523  Clustered mitochondria protein
 IPR028275  Clustered mitochondria protein, N-terminal
 IPR033646  CLU central domain
 IPR036388  Winged helix-like DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0048312 intracellular distribution of mitochondria IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cluhtm1.1Eir/Cluhtm1.1Eir,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/cJ * C57BL/6 * DBA * SJL

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Omptm4(cre)Mom/Omp+,Ric8btm1c(EUCOMM)Hmgu/Ric8btm1c(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

Allelic Composition: Cluhtm1.1Eir/Cluhtm1.1Eir,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/cJ * C57BL/6 * DBA * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Omptm4(cre)Mom/Omp+,Ric8btm1c(EUCOMM)Hmgu/Ric8btm1c(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Omptm4(cre)Mom/Omp+,Ric8btm1c(EUCOMM)Hmgu/Ric8btm1c(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

Allelic Composition: Cluhtm1.1Eir/Cluhtm1.1Eir,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/cJ * C57BL/6 * DBA * SJL

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cluhtm1.1Eir/Cluhtm1.1Eir,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/cJ * C57BL/6 * DBA * SJL

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
Show

Allelic Composition: Cluhtm1.1Eir/Cluhtm1.1Eir,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/cJ * C57BL/6 * DBA * SJL

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Omptm4(cre)Mom/Omp+,Ric8btm1c(EUCOMM)Hmgu/Ric8btm1c(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

Allelic Composition: Cluhtm1.1Eir/Cluhtm1.1Eir,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/cJ * C57BL/6 * DBA * SJL

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cluhtm1.1Eir/Cluhtm1.1Eir,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/cJ * C57BL/6 * DBA * SJL

 MP:0009138 increased brown fat lipid droplet number "increase in the number of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cluhtm1.1Eir/Cluhtm1.1Eir,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/cJ * C57BL/6 * DBA * SJL

 MP:0009429 decreased embryo weight "reduced weight of an embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Omptm4(cre)Mom/Omp+,Ric8btm1c(EUCOMM)Hmgu/Ric8btm1c(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
Show

Allelic Composition: Cluhtm1.1Eir/Cluhtm1.1Eir,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/cJ * C57BL/6 * DBA * SJL

 MP:0010958 abnormal tricarboxylic acid cycle "any anomaly in the universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes; the acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle" [GO:0006099]
Show

Allelic Composition: Omptm4(cre)Mom/Omp+,Ric8btm1c(EUCOMM)Hmgu/Ric8btm1c(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Omptm4(cre)Mom/Omp+,Ric8btm1c(EUCOMM)Hmgu/Ric8btm1c(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

 MP:0011637 abnormal mitochondrial matrix morphology "any structural anomaly of the gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion, and contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation" [GO:0005759]
Show

Allelic Composition: Omptm4(cre)Mom/Omp+,Ric8btm1c(EUCOMM)Hmgu/Ric8btm1c(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Omptm4(cre)Mom/Omp+,Ric8btm1c(EUCOMM)Hmgu/Ric8btm1c(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

Allelic Composition: Cluhtm1.1Eir/Cluhtm1.1Eir,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/cJ * C57BL/6 * DBA * SJL

 MP:0020237 increased proline level "higher than normal concentration of proline and its metabolic derivatives, derived from the amino acid L-glutamate" [ISBN10:1572591536]
Show

Allelic Composition: Cluhtm1.1Eir/Cluhtm1.1Eir,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/cJ * C57BL/6 * DBA * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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