Manteia - Molecule gene

ENSMUSG00000020774

Mus musculus

Features

Gene ID:	ENSMUSG00000020774

Biological name :	Aspa

Synonyms :	Aspa / aspartoacylase / Q8R3P0

Possible biological names infered from orthology :	P45381

Species:	Mus musculus

Chr. number:	11
Strand:	-1
Band:	B4
Gene start:	73304992
Gene end:	73329596

Corresponding Affymetrix probe sets:	10388254 (MoGene1.0st) 1418472_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000021119 Ensembl peptide - ENSMUSP00000121135 Ensembl peptide - ENSMUSP00000139131 Ensembl peptide - ENSMUSP00000139318 Ensembl peptide - ENSMUSP00000118109 NCBI entrez gene - 11484 See in Manteia. MGI - MGI:87914 RefSeq - XM_011248673 RefSeq - XM_006532010 RefSeq - XM_006532011 RefSeq - XM_006532012 RefSeq - XM_006532013 RefSeq - XM_011248672 RefSeq - NM_023113 RefSeq Peptide - NP_075602 swissprot - D6RJ20 swissprot - B0QZP3 swissprot - Q8R3P0 swissprot - V9GXG0 Ensembl - ENSMUSG00000020774

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
aspa	ENSDARG00000005154	Danio rerio
ASPA	ENSGALG00000004669	Gallus gallus
ASPA	ENSG00000108381	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Acy3 / Q91XE4 / N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) / Q96HD9* / aminoacylase 3*	ENSMUSG00000024866	42

Protein motifs (from Interpro)

Interpro ID	Name
IPR007036	Succinylglutamate desuccinylase/aspartoacylase
IPR016708	Aspartoacylase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006083	acetate metabolic process	TAS
biological_process	GO:0008152	metabolic process	IEA
biological_process	GO:0022010	central nervous system myelination	IEA
biological_process	GO:0048714	positive regulation of oligodendrocyte differentiation	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	IEA
molecular_function	GO:0004046	aminoacylase activity	TAS
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	IEA
molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	IEA
molecular_function	GO:0019807	aspartoacylase activity	IEA
molecular_function	GO:0042802	identical protein binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

Amino acid synthesis and interconversion (transamination)

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Aspa^tm1Mata/Aspa^tm1Mata Genetic Background: involves: 129S5/SvEvBrd
MP:0000434	megacephaly	"an abnormally large size of the head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Aspa^tm1Mata/Aspa^tm1Mata Genetic Background: involves: 129S5/SvEvBrd
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele Genetic Background: Not Specified Allelic Composition: Aspa^tm1Mata/Aspa^tm1Mata Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Aspa^deaf14/Aspa^deaf14 Genetic Background: BALB/c-Aspa^deaf14
MP:0000747	muscle weakness	"loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Aspa^{tm1a(EUCOMM)Wtsi}/Aspa^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0000753	paralysis	"loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Aspa^{tm1a(EUCOMM)Wtsi}/Aspa^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0000830	abnormal diencephalon morphology	"any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Aspa^tm1Mata/Aspa^tm1Mata Genetic Background: involves: 129S5/SvEvBrd
MP:0000920	abnormal myelination	"atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele Genetic Background: Not Specified Allelic Composition: Aspa^nur7/Aspa^nur7,Ugt8a^tm1Pop/Ugt8a⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0000921	demyelination	"loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele Genetic Background: Not Specified
MP:0000953	abnormal oligodendrocyte morphology	"anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele Genetic Background: Not Specified
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Aspa^tm1Mata/Aspa^tm1Mata Genetic Background: involves: 129S5/SvEvBrd
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele Genetic Background: Not Specified Allelic Composition: Aspa^tm1Mata/Aspa^tm1Mata Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Aspa^{tm1a(EUCOMM)Wtsi}/Aspa^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N Allelic Composition: Aspa^nur7/Aspa^nur7,Nat8l^tm1.2Meck/Nat8l⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele Genetic Background: Not Specified Allelic Composition: Aspa^{tm1a(EUCOMM)Wtsi}/Aspa^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0001312	abnormal cornea morphology	"malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Arvcf^{tm1e(EUCOMM)Wtsi}/Arvcf^{tm1e(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Arvcf^{tm1e(EUCOMM)Wtsi}/Ieg
MP:0001314	corneal opacity	"complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Aspa^{tm1b(EUCOMM)Wtsi}/Aspa^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Aspa^{tm1b(EUCOMM)Wtsi}/Ieg
MP:0001364	decreased anxiety-related response	"when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(H1/tetO-RNAi:Pdpk1)Mrl}/Gt(ROSA)26Sor⁺,Pten^tm1.1Hwu/Pten⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6NTac
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele Genetic Background: Not Specified Allelic Composition: Aspa^tm1Mata/Aspa^tm1Mata Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Aspa^deaf14/Aspa^deaf14 Genetic Background: BALB/c-Aspa^deaf14
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Aspa^deaf14/Aspa^deaf14 Genetic Background: BALB/c-Aspa^deaf14 Allelic Composition: Aspa^{tm1b(EUCOMM)Wtsi}/Aspa^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Aspa^{tm1b(EUCOMM)Wtsi}/Ieg
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele Genetic Background: Not Specified Allelic Composition: Aspa^{tm1a(EUCOMM)Wtsi}/Aspa^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N Allelic Composition: Aspa^nur7/Aspa^nur7,Nat8l^tm1.2Meck/Nat8l⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J Allelic Composition: Aspa^{tm1b(EUCOMM)Wtsi}/Aspa^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Aspa^{tm1b(EUCOMM)Wtsi}/Ieg
MP:0001405	impaired coordination	"reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele Genetic Background: Not Specified Allelic Composition: Aspa^nur7/Aspa^nur7,Ugt8a^tm1Pop/Ugt8a⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Aspa^{tm1a(EUCOMM)Wtsi}/Aspa^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N Allelic Composition: Aspa^deaf14/Aspa^deaf14 Genetic Background: BALB/c-Aspa^deaf14
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele Genetic Background: Not Specified Allelic Composition: Aspa^tm1Mata/Aspa^tm1Mata Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Aspa^{tm1a(EUCOMM)Wtsi}/Aspa^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N Allelic Composition: Aspa^{tm1b(EUCOMM)Wtsi}/Aspa^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Aspa^{tm1b(EUCOMM)Wtsi}/Ieg
MP:0001489	decreased startle reflex	"greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]	Show Allelic Composition: Aspa^deaf14/Aspa^deaf14 Genetic Background: BALB/c-Aspa^deaf14 Allelic Composition: Aspa^{tm1b(EUCOMM)Wtsi}/Aspa^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Aspa^{tm1b(EUCOMM)Wtsi}/Ieg
MP:0001513	limb grasping	"mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Arvcf^{tm1e(EUCOMM)Wtsi}/Arvcf^{tm1e(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Arvcf^{tm1e(EUCOMM)Wtsi}/Ieg
MP:0001970	abnormal pain threshold	"increased or decreased average level of perception of pain" [J:17792]	Show Allelic Composition: Aspa^tm1Mata/Aspa^tm1Mata Genetic Background: involves: 129S5/SvEvBrd
MP:0002064	seizures	"sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele Genetic Background: Not Specified
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele Genetic Background: Not Specified Allelic Composition: Aspa^tm1Mata/Aspa^tm1Mata Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Aspa^nur7/Aspa^nur7,Nat8l^tm1.2Meck/Nat8l^tm1.2Meck Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J
MP:0002152	abnormal brain morphology	"anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]	Show Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele Genetic Background: Not Specified Allelic Composition: Aspa^nur7/Aspa^nur7,Nat8l^tm1.2Meck/Nat8l⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Aspa^{tm1a(EUCOMM)Wtsi}/Aspa^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0002182	abnormal astrocyte morphology	"anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Aspa^nur7/Aspa^nur7,Nat8l^tm1.2Meck/Nat8l^tm1.2Meck Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J
MP:0002183	gliosis	"increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Aspa^{tm1a(EUCOMM)Wtsi}/Aspa^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0002204	abnormal neurotransmitter physiology	"aberrant function or production of endogenous signaling molecules secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Aspa^tm1Mata/Aspa^tm1Mata Genetic Background: involves: 129S5/SvEvBrd
MP:0002590	increased mean corpuscular volume	"greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Aspa^{tm1b(EUCOMM)Wtsi}/Aspa^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Aspa^{tm1b(EUCOMM)Wtsi}/Ieg
MP:0002654	spongiform encephalopathy	"a neurodegenerative state characterized by the appearance of large vacuolated areas in the brain cells, resembling a sponge" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele Genetic Background: Not Specified Allelic Composition: Aspa^tm1Mata/Aspa^tm1Mata Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Aspa^nur7/Aspa^nur7,Ugt8a^tm1Pop/Ugt8a⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Aspa^{tm1a(EUCOMM)Wtsi}/Aspa^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N Allelic Composition: Aspa^nur7/Aspa^nur7,Nat8l^tm1.2Meck/Nat8l⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J Allelic Composition: Aspa^deaf14/Aspa^deaf14 Genetic Background: BALB/c-Aspa^deaf14
MP:0002757	reduced vertical activity	"lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele Genetic Background: Not Specified Allelic Composition: Aspa^nur7/Aspa^nur7,Nat8l^tm1.2Meck/Nat8l⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J Allelic Composition: Aspa^{tm1b(EUCOMM)Wtsi}/Aspa^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Aspa^{tm1b(EUCOMM)Wtsi}/Ieg
MP:0003354	astrocytosis	"a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele Genetic Background: Not Specified Allelic Composition: Aspa^nur7/Aspa^nur7,Nat8l^tm1.2Meck/Nat8l⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J
MP:0003961	decreased lean body mass	"less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Aspa^{tm1b(EUCOMM)Wtsi}/Aspa^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Aspa^{tm1b(EUCOMM)Wtsi}/Ieg
MP:0004142	abnormal muscle tone	"anomaly in the resting tautness or laxity of a muscle, normally somewhere in the middle of the range between total contraction and total relaxation" [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Aspa^{tm1a(EUCOMM)Wtsi}/Aspa^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0004143	hypertonia	"increased muscle tone" [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Aspa^{tm1a(EUCOMM)Wtsi}/Aspa^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0004924	abnormal behavior	"anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Aspa^{tm1b(EUCOMM)Wtsi}/Aspa^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Aspa^{tm1b(EUCOMM)Wtsi}/Ieg
MP:0005202	lethargy	"mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele Genetic Background: Not Specified Allelic Composition: Aspa^tm1Mata/Aspa^tm1Mata Genetic Background: involves: 129S5/SvEvBrd
MP:0005241	abnormal retinal ganglion layer morphology	"anomalous structure of the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Aspa^tm1Mata/Aspa^tm1Mata Genetic Background: involves: 129S5/SvEvBrd
MP:0005277	abnormal brainstem morphology	"anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]	Show Allelic Composition: Aspa^tm1Mata/Aspa^tm1Mata Genetic Background: involves: 129S5/SvEvBrd
MP:0005319	abnormal enzyme/ coenzyme level	"altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele Genetic Background: Not Specified Allelic Composition: Aspa^nur7/Aspa^nur7,Nat8l^tm1.2Meck/Nat8l^tm1.2Meck Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J Allelic Composition: Aspa^nur7/Aspa^nur7,Nat8l^tm1.2Meck/Nat8l⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J
MP:0005405	axon degeneration	"retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele Genetic Background: Not Specified
MP:0005424	jerky movement	"continuous, abrupt, faltering motions of the whole body or a portion of the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Aspa^{tm1a(EUCOMM)Wtsi}/Aspa^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0006303	abnormal retinal nerve fiber layer morphology	"malformation of the layer of the retina formed by expansion of the fibers of the optic nerve" [ISBN:0-914294-08-3 "Gray s Anatomy", J:67382, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Aspa^tm1Mata/Aspa^tm1Mata Genetic Background: involves: 129S5/SvEvBrd
MP:0008025	brain vacuoles	"the abnormal presence of cavities or fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele Genetic Background: Not Specified Allelic Composition: Aspa^nur7/Aspa^nur7,Nat8l^tm1.2Meck/Nat8l⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J Allelic Composition: Aspa^deaf14/Aspa^deaf14 Genetic Background: BALB/c-Aspa^deaf14
MP:0008026	abnormal brain white matter morphology	"any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele Genetic Background: Not Specified
MP:0008535	enlarged lateral ventricles	"increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele Genetic Background: Not Specified
MP:0009142	decreased prepulse inhibition	"decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Aspa^{tm1b(EUCOMM)Wtsi}/Aspa^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Aspa^{tm1b(EUCOMM)Wtsi}/Ieg
MP:0009808	reduced oligodendrocyte number	"significantly fewer than the expected number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS are present" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Aspa^nur7/Aspa^nur7,Ugt8a^tm1Pop/Ugt8a⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Aspa^tm1Mata/Aspa^tm1Mata Genetic Background: involves: 129S5/SvEvBrd
MP:0010053	decreased grip strength	"reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Aspa^{tm1b(EUCOMM)Wtsi}/Aspa^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Aspa^{tm1b(EUCOMM)Wtsi}/Ieg
MP:0010124	decreased bone mineral content	"reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Aspa^tm1Mata/Aspa^tm1Mata Genetic Background: involves: 129S5/SvEvBrd
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Aspa^tm1Mata/Aspa^tm1Mata Genetic Background: involves: 129S5/SvEvBrd
MP:0011966	abnormal auditory brainstem response waveform shape	"any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]	Show Allelic Composition: Aspa^deaf14/Aspa^deaf14 Genetic Background: BALB/c-Aspa^deaf14
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Aspa^deaf14/Aspa^deaf14 Genetic Background: BALB/c-Aspa^deaf14 Allelic Composition: Aspa^{tm1b(EUCOMM)Wtsi}/Aspa^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Aspa^{tm1b(EUCOMM)Wtsi}/Ieg
MP:0012230	abnormal sphingolipid level		Show Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele Genetic Background: Not Specified
MP:0013279	increased fasted circulating glucose level	"increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]	Show Allelic Composition: Aspa^{tm1b(EUCOMM)Wtsi}/Aspa^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Aspa^{tm1b(EUCOMM)Wtsi}/Ieg

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000020774	Aspa / Q8R3P0 / aspartoacylase / P45381*	/ complex

1 s.

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