ENSMUSG00000020802


Mus musculus

Features
Gene ID: ENSMUSG00000020802
  
Biological name :Ube2o
  
Synonyms : Q6ZPJ3 / Ube2o / ubiquitin-conjugating enzyme E2O
  
Possible biological names infered from orthology : Q9C0C9
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 116537740
Gene end: 116581447
  
Corresponding Affymetrix probe sets: 10393320 (MoGene1.0st)   1433765_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000080791
NCBI entrez gene - 217342     See in Manteia.
MGI - MGI:2444266
RefSeq - NM_173755
RefSeq - XM_006533106
RefSeq Peptide - NP_776116
swissprot - Q6ZPJ3
Ensembl - ENSMUSG00000020802
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01060453.1ENSDARG00000100674Danio rerio
 UBE2OENSGALG00000001971Gallus gallus
 UBE2OENSG00000175931Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Birc6 / O88738 / Baculoviral IAP repeat-containing protein 6 / Q9NR09* / baculoviral IAP repeat containing 6*ENSMUSG0000002407323
Ube2z / Q3UE37 / ubiquitin-conjugating enzyme E2Z / Q9H832*ENSMUSG000000143497


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006513 protein monoubiquitination IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030513 positive regulation of BMP signaling pathway IEA
 biological_processGO:0042147 retrograde transport, endosome to Golgi IEA
 biological_processGO:0070534 protein K63-linked ubiquitination IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IBA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA
 molecular_functionGO:0061631 ubiquitin conjugating enzyme activity IEA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001273 decreased metastatic potential 
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Allelic Composition: Ube2otm1.1(KOMP)Mbp/Ube2o+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Srd5a3tm1b(EUCOMM)Wtsi/Srd5a3tm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Srd5a3tm1b(EUCOMM)Wtsi/J

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Srd5a3tm1b(EUCOMM)Wtsi/Srd5a3tm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Srd5a3tm1b(EUCOMM)Wtsi/J

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ube2otm1.1(KOMP)Mbp/Ube2o+,Tg(TRAMP)8247Ng/0
Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fgfbp1tm1Gvdz/Fgfbp1tm1Gvdz,Tg(Thy1-YFP)16Jrs/0
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * CBA

 MP:0003344 mammary gland hypoplasia "decreased size of mammary gland due to decreased cell number" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Fgfbp1tm1Gvdz/Fgfbp1tm1Gvdz,Tg(Thy1-YFP)16Jrs/0
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * CBA

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Fgfbp1tm1Gvdz/Fgfbp1tm1Gvdz,Tg(Thy1-YFP)16Jrs/0
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * CBA

Allelic Composition: Ube2otm1.1(KOMP)Mbp/Ube2o+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N

Allelic Composition: Ube2otm1.1(KOMP)Mbp/Ube2otm1.1(KOMP)Mbp,Tg(TRAMP)8247Ng/0
Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N

Allelic Composition: Ube2otm1.1(KOMP)Mbp/Ube2o+,Tg(TRAMP)8247Ng/0
Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Srd5a3tm1b(EUCOMM)Wtsi/Srd5a3tm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Srd5a3tm1b(EUCOMM)Wtsi/J

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Srd5a3tm1b(EUCOMM)Wtsi/Srd5a3tm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Srd5a3tm1b(EUCOMM)Wtsi/J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfbp1tm1Gvdz/Fgfbp1tm1Gvdz,Tg(Thy1-YFP)16Jrs/0
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * CBA

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ube2otm1.1(KOMP)Mbp/Ube2o+,Tg(TRAMP)8247Ng/0
Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N

 MP:0009828 delayed tumor appearance "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Fgfbp1tm1Gvdz/Fgfbp1tm1Gvdz,Tg(Thy1-YFP)16Jrs/0
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * CBA

Allelic Composition: Ube2otm1.1(KOMP)Mbp/Ube2o+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Srd5a3tm1b(EUCOMM)Wtsi/Srd5a3tm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Srd5a3tm1b(EUCOMM)Wtsi/J

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Srd5a3tm1b(EUCOMM)Wtsi/Srd5a3tm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Srd5a3tm1b(EUCOMM)Wtsi/J

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfbp1tm1Gvdz/Fgfbp1tm1Gvdz,Tg(Thy1-YFP)16Jrs/0
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * CBA

Allelic Composition: Ube2otm1.1(KOMP)Mbp/Ube2o+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Srd5a3tm1b(EUCOMM)Wtsi/Srd5a3tm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Srd5a3tm1b(EUCOMM)Wtsi/J

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Fgfbp1tm1Gvdz/Fgfbp1tm1Gvdz,Tg(Thy1-YFP)16Jrs/0
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * CBA

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Ube2otm1.1(KOMP)Mbp/Ube2otm1.1(KOMP)Mbp,Ptentm1Ppp/Ptentm1Ppp
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6N * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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