ENSMUSG00000024073


Mus musculus

Features
Gene ID: ENSMUSG00000024073
  
Biological name :Birc6
  
Synonyms : Baculoviral IAP repeat-containing protein 6 / Birc6 / O88738
  
Possible biological names infered from orthology : baculoviral IAP repeat containing 6 / Q9NR09
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: E2
Gene start: 74528295
Gene end: 74703356
  
Corresponding Affymetrix probe sets: 10446833 (MoGene1.0st)   1419562_at (Mouse Genome 430 2.0 Array)   1419563_at (Mouse Genome 430 2.0 Array)   1427488_a_at (Mouse Genome 430 2.0 Array)   1437789_at (Mouse Genome 430 2.0 Array)   1442495_at (Mouse Genome 430 2.0 Array)   1442959_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138732
Ensembl peptide - ENSMUSP00000138693
Ensembl peptide - ENSMUSP00000138717
Ensembl peptide - ENSMUSP00000136329
Ensembl peptide - ENSMUSP00000137114
Ensembl peptide - ENSMUSP00000138270
Ensembl peptide - ENSMUSP00000138333
Ensembl peptide - ENSMUSP00000138343
Ensembl peptide - ENSMUSP00000138349
Ensembl peptide - ENSMUSP00000138521
Ensembl peptide - ENSMUSP00000138672
NCBI entrez gene - 12211     See in Manteia.
MGI - MGI:1276108
RefSeq - XM_011246257
RefSeq - XM_006523518
RefSeq - XM_006523519
RefSeq - XM_006523520
RefSeq - XM_006523521
RefSeq - XM_006523522
RefSeq - XM_006523523
RefSeq - XM_006523524
RefSeq - XM_006523526
RefSeq - XM_006523527
RefSeq - XM_006523528
RefSeq - XM_006523529
RefSeq - NM_007566
RefSeq Peptide - NP_031592
swissprot - A0A1S6GWH3
swissprot - O88738
swissprot - S4R1L5
swissprot - S4R1R8
swissprot - S4R1S3
swissprot - S4R268
swissprot - S4R2J7
swissprot - S4R2N7
swissprot - J3QP64
swissprot - S4R2P8
Ensembl - ENSMUSG00000024073
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 birc6ENSDARG00000074166Danio rerio
 BIRC6ENSGALG00000010541Gallus gallus
 BIRC6ENSG00000115760Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ube2o / Q6ZPJ3 / ubiquitin-conjugating enzyme E2O / Q9C0C9*ENSMUSG000000208026
Ube2z / Q3UE37 / ubiquitin-conjugating enzyme E2Z / Q9H832*ENSMUSG000000143492


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR001370  BIR repeat
 IPR008979  Galactose-binding-like domain superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR022103  Baculoviral IAP repeat-containing protein 6
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001890 placenta development IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0009966 regulation of signal transduction IBA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0032465 regulation of cytokinesis IEA
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060711 labyrinthine layer development IMP
 biological_processGO:0060712 spongiotrophoblast layer development IMP
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway ISO
 cellular_componentGO:0000922 spindle pole ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network ISO
 cellular_componentGO:0005815 microtubule organizing center ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0090543 Flemming body IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0004869 cysteine-type endopeptidase inhibitor activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0061631 ubiquitin conjugating enzyme activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Egr2tm1Jmi/Egr2tm1Jmi
Genetic Background: Not Specified

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000606 decreased hepatocyte number "fewer than normal number of parenchymal liver cells" [J:23170]
Show

Allelic Composition: Egr2tm1Jmi/Egr2tm1Jmi
Genetic Background: Not Specified

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Hprtb-m3/Y,Impdh1tm1Bmi/Impdh1tm1Bmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Egr2tm1Jmi/Egr2tm1Jmi
Genetic Background: Not Specified

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001917 intraventricular hemorrhage "bleeding into the brain ventricles" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hprtb-m3/Y,Impdh1tm1Bmi/Impdh1tm1Bmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Egr2tm1Jmi/Egr2tm1Jmi
Genetic Background: Not Specified

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003396 abnormal embryonic hematopoiesis "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans " [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Egr2tm1Jmi/Egr2tm1Jmi
Genetic Background: Not Specified

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004255 abnormal spongiotrophoblast layer morphology "anomaly in the structure of the outer structural layer of the rodent placenta" [PMID:11433360]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rasgrp1tm1Jstn/Rasgrp1tm1Jstn
Genetic Background: involves: 129P3/J

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Egr2tm1Jmi/Egr2tm1Jmi
Genetic Background: Not Specified

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

Allelic Composition: Birc6tm1Nai/Birc6tm1Nai
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Birc6tm1Nai/Birc6tm1Nai
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Birc6tm1Nai/Birc6tm1Nai
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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