ENSMUSG00000020829


Mus musculus

Features
Gene ID: ENSMUSG00000020829
  
Biological name :Slc46a1
  
Synonyms : Q6PEM8 / Slc46a1 / solute carrier family 46, member 1
  
Possible biological names infered from orthology : Q96NT5
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 78465697
Gene end: 78472059
  
Corresponding Affymetrix probe sets: 10379184 (MoGene1.0st)   1426714_at (Mouse Genome 430 2.0 Array)   1426715_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001126
Ensembl peptide - ENSMUSP00000119800
NCBI entrez gene - 52466     See in Manteia.
MGI - MGI:1098733
RefSeq - NM_026740
RefSeq Peptide - NP_081016
swissprot - F6QD87
swissprot - Q6PEM8
Ensembl - ENSMUSG00000020829
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc46a1ENSDARG00000026149Danio rerio
 SLC46A1ENSGALG00000003604Gallus gallus
 Q96NT5ENSG00000076351Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9DC26 / Slc46a3 / Solute carrier family 46 member 3 / Q7Z3Q1*ENSMUSG0000002965029
Q8CA03 / Slc46a2 / solute carrier family 46, member 2 / Q9BY10*ENSMUSG0000002838623


Protein motifs (from Interpro)
Interpro ID Name
 IPR005829  Sugar transporter, conserved site
 IPR011701  Major facilitator superfamily
 IPR020846  Major facilitator superfamily domain
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015884 folic acid transport IEA
 biological_processGO:0015886 heme transport IDA
 biological_processGO:0051958 methotrexate transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:1902600 proton transmembrane transport IEA
 biological_processGO:1904447 folate import across plasma membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031526 brush border membrane IEA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0005542 folic acid binding IEA
 molecular_functionGO:0008517 folic acid transmembrane transporter activity IEA
 molecular_functionGO:0015078 proton transmembrane transporter activity IEA
 molecular_functionGO:0015232 heme transporter activity IDA
 molecular_functionGO:0015350 methotrexate transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Metabolism of folate and pterines
Iron uptake and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gtpbp2tm1b(KOMP)Mbp/Gtpbp2+
Genetic Background: C57BL/6N-Gtpbp2tm1b(KOMP)Mbp/Ucd

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gtpbp2tm1b(KOMP)Mbp/Gtpbp2+
Genetic Background: C57BL/6N-Gtpbp2tm1b(KOMP)Mbp/Ucd

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gtpbp2tm1b(KOMP)Mbp/Gtpbp2+
Genetic Background: C57BL/6N-Gtpbp2tm1b(KOMP)Mbp/Ucd

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Runx1t1tm1Fc/Runx1t1+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gtpbp2tm1b(KOMP)Mbp/Gtpbp2+
Genetic Background: C57BL/6N-Gtpbp2tm1b(KOMP)Mbp/Ucd

 MP:0006076 abnormal circulating homocysteine level "aberrant concentration in the blood of this amino acid" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
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Allelic Composition: Runx1t1tm1Fc/Runx1t1+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gtpbp2tm1b(KOMP)Mbp/Gtpbp2+
Genetic Background: C57BL/6N-Gtpbp2tm1b(KOMP)Mbp/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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