ENSMUSG00000020898


Mus musculus

Features
Gene ID: ENSMUSG00000020898
  
Biological name :Ctc1
  
Synonyms : CST complex subunit CTC1 / Ctc1 / Q5SUQ9
  
Possible biological names infered from orthology : CST telomere replication complex component 1 / Q2NKJ3
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 69015911
Gene end: 69036473
  
Corresponding Affymetrix probe sets: 10377380 (MoGene1.0st)   1423655_a_at (Mouse Genome 430 2.0 Array)   1423656_x_at (Mouse Genome 430 2.0 Array)   1437713_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125028
Ensembl peptide - ENSMUSP00000021278
Ensembl peptide - ENSMUSP00000112063
Ensembl peptide - ENSMUSP00000124702
NCBI entrez gene - 68964     See in Manteia.
MGI - MGI:1916214
RefSeq - XM_017314733
RefSeq - NM_001143790
RefSeq - NM_001281464
RefSeq - NM_001281465
RefSeq - XM_006534088
RefSeq - XM_006534089
RefSeq - XM_006534092
RefSeq - XM_006534093
RefSeq - NM_001013256
RefSeq Peptide - NP_001268394
RefSeq Peptide - NP_001013274
RefSeq Peptide - NP_001137262
RefSeq Peptide - NP_001268393
swissprot - Q5SUQ9
swissprot - E0CXT1
swissprot - E0CXE7
Ensembl - ENSMUSG00000020898
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctc1ENSDARG00000070119Danio rerio
 CTC1ENSGALG00000032036Gallus gallus
 CTC1ENSG00000178971Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR029156  CST complex subunit CTC1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000723 telomere maintenance IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007568 aging IMP
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle IMP
 biological_processGO:0010833 telomere maintenance via telomere lengthening IMP
 biological_processGO:0032211 negative regulation of telomere maintenance via telomerase IEA
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0045740 positive regulation of DNA replication IDA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IMP
 biological_processGO:0048536 spleen development IMP
 biological_processGO:0048538 thymus development IMP
 biological_processGO:0048539 bone marrow development IMP
 biological_processGO:0051276 chromosome organization IMP
 biological_processGO:0071425 hematopoietic stem cell proliferation IMP
 biological_processGO:0090399 replicative senescence IMP
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:1990879 CST complex IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042162 telomeric DNA binding IEA
 molecular_functionGO:0098505 G-rich strand telomeric DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003155 abnormal telomere length "abnormal length of the terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability; normal length is a few hundred base pairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0009335 decreased splenocyte proliferation "reduction in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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