ENSMUSG00000020903


Mus musculus

Features
Gene ID: ENSMUSG00000020903
  
Biological name :Stx8
  
Synonyms : O88983 / Stx8 / syntaxin 8
  
Possible biological names infered from orthology : Q9UNK0
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 67966193
Gene end: 68207148
  
Corresponding Affymetrix probe sets: 10377255 (MoGene1.0st)   1418088_a_at (Mouse Genome 430 2.0 Array)   1418089_at (Mouse Genome 430 2.0 Array)   1453631_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021285
Ensembl peptide - ENSMUSP00000021286
Ensembl peptide - ENSMUSP00000104315
NCBI entrez gene - 55943     See in Manteia.
MGI - MGI:1890156
RefSeq - XM_011249133
RefSeq - NM_001356314
RefSeq - NM_018768
RefSeq Peptide - NP_061238
RefSeq Peptide - NP_001343243
swissprot - O88983
swissprot - Q8BS59
swissprot - Q9D0J1
Ensembl - ENSMUSG00000020903
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stx8ENSDARG00000103173Danio rerio
 STX8ENSGALG00000001238Gallus gallus
 STX8ENSG00000170310Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000727  Target SNARE coiled-coil homology domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IBA
 biological_processGO:0006906 vesicle fusion IEA
 biological_processGO:0008333 endosome to lysosome transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0045022 early endosome to late endosome transport IEA
 biological_processGO:0048278 vesicle docking IBA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 biological_processGO:1903076 regulation of protein localization to plasma membrane IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0012505 endomembrane system IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0031201 SNARE complex IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0045335 phagocytic vesicle IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0000149 SNARE binding IBA
 molecular_functionGO:0005484 SNAP receptor activity IBA
 molecular_functionGO:0019869 chloride channel inhibitor activity IEA
 molecular_functionGO:0019905 syntaxin binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sirt2tm1a(EUCOMM)Wtsi/Sirt2tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Spns2tm1a(KOMP)Wtsi/Wtsi

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0009446 abnormal platelet dense granule physiology "any functional anomaly of the specialized secretory organelles located in the small, irregularly shaped anuclear cells derived from fragmentation of precursor megakaryocytes that contain adenine nucleotides (ADP and ATP), ionized calcium, histamine, serotonin, and epinephrine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Spns2tm1a(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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