ENSMUSG00000021013


Mus musculus

Features
Gene ID: ENSMUSG00000021013
  
Biological name :Ttc8
  
Synonyms : Q8VD72 / tetratricopeptide repeat domain 8 / Ttc8
  
Possible biological names infered from orthology : Q8TAM2
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: E
Gene start: 98920574
Gene end: 98983238
  
Corresponding Affymetrix probe sets: 10397683 (MoGene1.0st)   1424410_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078148
Ensembl peptide - ENSMUSP00000082190
Ensembl peptide - ENSMUSP00000115828
NCBI entrez gene - 76260     See in Manteia.
MGI - MGI:1923510
RefSeq - XM_017315241
RefSeq - NM_029553
RefSeq - NM_198311
RefSeq Peptide - NP_083829
RefSeq Peptide - NP_938053
swissprot - Q8VD72
swissprot - D3YYH2
Ensembl - ENSMUSG00000021013
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TTC8ENSGALG00000010663Gallus gallus
 TTC8ENSG00000165533Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bbs4 / Q8C1Z7 / Bardet-Biedl syndrome 4 protein homolog / Q96RK4* / Bardet-Biedl syndrome 4*ENSMUSG0000002523517


Protein motifs (from Interpro)
Interpro ID Name
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR028796  Tetratricopeptide repeat protein 8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001736 establishment of planar polarity IMP
 biological_processGO:0007411 axon guidance IGI
 biological_processGO:0007608 sensory perception of smell IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0021772 olfactory bulb development IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0032880 regulation of protein localization IMP
 biological_processGO:0034260 negative regulation of GTPase activity IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0045444 fat cell differentiation IEP
 biological_processGO:0048560 establishment of anatomical structure orientation ISO
 biological_processGO:0051492 regulation of stress fiber assembly IMP
 biological_processGO:0060122 inner ear receptor cell stereocilium organization IMP
 biological_processGO:0060219 camera-type eye photoreceptor cell differentiation IMP
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0061326 renal tubule development IMP
 biological_processGO:0072659 protein localization to plasma membrane IMP
 biological_processGO:1903251 multi-ciliated epithelial cell differentiation IMP
 biological_processGO:1905515 non-motile cilium assembly IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005929 cilium ISO
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0032391 photoreceptor connecting cilium IDA
 cellular_componentGO:0034464 BBSome IEA
 cellular_componentGO:0036064 ciliary basal body ISO
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0060170 ciliary membrane IEA
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding ISO
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
BBSome-mediated cargo-targeting to cilium


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccdc88atm3.1Mat/Ccdc88atm3.1Mat
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Ccdc88atm3.1Mat/Ccdc88atm3.1Mat
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Ccdc88atm3.1Mat/Ccdc88atm3.1Mat
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ccdc88atm3.1Mat/Ccdc88atm3.1Mat
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Ccdc88atm3.1Mat/Ccdc88atm3.1Mat
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Olfr17tm1Mom/Olfr17+,Ttc8tm1Reed/Ttc8tm1Reed
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0003730 abnormal photoreceptor inner segments "malformation/anomalous structure of the photoreceptor layer which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccdc88atm3.1Mat/Ccdc88atm3.1Mat
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccdc88atm3.1Mat/Ccdc88atm3.1Mat
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008544 impaired olfaction "reduced ability to detect odors" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccdc88atm3.1Mat/Ccdc88atm3.1Mat
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009450 abnormal axon fasiculation "anomaly in the process by which axons form into bundles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccdc88atm3.1Mat/Ccdc88atm3.1Mat
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ccdc88atm3.1Mat/Ccdc88atm3.1Mat
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011281 abnormal olfactory epithelium cilium morphology "any structural anomaly of the cilia of the epithelial cells that line the interior of the nose" [MGI:smb]
Show

Allelic Composition: Ccdc88atm3.1Mat/Ccdc88atm3.1Mat
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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