ENSMUSG00000021022


Mus musculus

Features
Gene ID: ENSMUSG00000021022
  
Biological name :Ppp2r3c
  
Synonyms : Ppp2r3c / Q9JK24 / Serine/threonine-protein phosphatase 2A regulatory subunit B subunit gamma
  
Possible biological names infered from orthology : protein phosphatase 2 regulatory subunit Bgamma / Q969Q6
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: C1
Gene start: 55278991
Gene end: 55302998
  
Corresponding Affymetrix probe sets: 10400395 (MoGene1.0st)   1417478_a_at (Mouse Genome 430 2.0 Array)   1417479_at (Mouse Genome 430 2.0 Array)   1453515_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021410
NCBI entrez gene - 59032     See in Manteia.
MGI - MGI:1930009
RefSeq - NM_021529
RefSeq Peptide - NP_067504
swissprot - Q9JK24
Ensembl - ENSMUSG00000021022
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp2r3cENSDARG00000043972Danio rerio
 PPP2R3CENSGALG00000010052Gallus gallus
 Q969Q6ENSG00000092020Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ppp2r3a / protein phosphatase 2 regulatory subunit Balpha / Q06190*ENSMUSG0000004315420
Ppp2r3d / serine/threonine-protein phosphatase 2A regulatory subunit B subunit delta isoform 2 / Q9Y5P8* / PPP2R3B* / protein phosphatase 2 regulatory subunit Bbeta*ENSMUSG000000938037


Protein motifs (from Interpro)
Interpro ID Name
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IBA
 biological_processGO:0001782 B cell homeostasis IMP
 biological_processGO:0002759 regulation of antimicrobial humoral response IMP
 biological_processGO:0030865 cortical cytoskeleton organization IBA
 biological_processGO:0032147 activation of protein kinase activity IMP
 biological_processGO:0043029 T cell homeostasis IMP
 biological_processGO:0045579 positive regulation of B cell differentiation IMP
 biological_processGO:0048536 spleen development IMP
 biological_processGO:0050864 regulation of B cell activation IMP
 biological_processGO:0051900 regulation of mitochondrial depolarization IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005819 spindle IBA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sox10tm4Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Sox10tm4Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sox10tm4Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sox10tm4Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sox10tm4Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
Show

Allelic Composition: Sox10tm4Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox10tm4Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox10tm4Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0008189 increased transitional stage B cell number "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox10tm4Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox10tm4Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox10tm4Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Sox10tm4Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox10tm4Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox10tm4Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0008484 decreased spleen germinal center size "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Sox10tm4Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd * C3H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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