ENSMUSG00000043154


Mus musculus

Features
Gene ID: ENSMUSG00000043154
  
Biological name :Ppp2r3a
  
Synonyms : Ppp2r3a / protein phosphatase 2 regulatory subunit Balpha
  
Possible biological names infered from orthology : Q06190
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: E4
Gene start: 101105084
Gene end: 101251795
  
Corresponding Affymetrix probe sets: 10596072 (MoGene1.0st)   1437869_at (Mouse Genome 430 2.0 Array)   1444612_at (Mouse Genome 430 2.0 Array)   1455091_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000069688
Ensembl peptide - ENSMUSP00000075327
NCBI entrez gene - 235542     See in Manteia.
MGI - MGI:2442104
RefSeq - XM_017313349
RefSeq - NM_172144
RefSeq - XM_006511704
RefSeq - XM_017313347
RefSeq - XM_017313348
RefSeq - NM_001161362
RefSeq Peptide - NP_742156
RefSeq Peptide - NP_001154834
swissprot - G3X9E8
swissprot - B2RXC8
Ensembl - ENSMUSG00000043154
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp2r3aENSDARG00000077722Danio rerio
 PPP2R3AENSGALG00000034512Gallus gallus
 Q06190ENSG00000073711Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ppp2r3d / serine/threonine-protein phosphatase 2A regulatory subunit B subunit delta isoform 2 / Q9Y5P8* / PPP2R3B* / protein phosphatase 2 regulatory subunit Bbeta*ENSMUSG000000938038
Q9JK24 / Ppp2r3c / Serine/threonine-protein phosphatase 2A regulatory subunit B subunit gamma / Q969Q6* / protein phosphatase 2 regulatory subunit Bgamma*ENSMUSG000000210228


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001754 eye photoreceptor cell differentiation ISO
 biological_processGO:0007525 somatic muscle development ISO
 biological_processGO:0045732 positive regulation of protein catabolic process ISO
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway ISO
 biological_processGO:0090249 regulation of cell motility involved in somitogenic axis elongation ISO
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway ISO
 cellular_componentGO:0000159 protein phosphatase type 2A complex ISO
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0030674 protein binding, bridging ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0003795 abnormal bone structure 
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Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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