ENSMUSG00000021266


Mus musculus

Features
Gene ID: ENSMUSG00000021266
  
Biological name :Wars
  
Synonyms : P32921 / tryptophanyl-tRNA synthetase / Wars
  
Possible biological names infered from orthology : P23381
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: F1
Gene start: 108860030
Gene end: 108894174
  
Corresponding Affymetrix probe sets: 10402585 (MoGene1.0st)   10338116 (MoGene1.0st)   10338280 (MoGene1.0st)   10339726 (MoGene1.0st)   10339750 (MoGene1.0st)   10339765 (MoGene1.0st)   10340809 (MoGene1.0st)   10341016 (MoGene1.0st)   10341289 (MoGene1.0st)   10341395 (MoGene1.0st)   10341579 (MoGene1.0st)   10342553 (MoGene1.0st)   10342761 (MoGene1.0st)   10343468 (MoGene1.0st)   10343623 (MoGene1.0st)   10339327 (MoGene1.0st)   10340298 (MoGene1.0st)   10340507 (MoGene1.0st)   10340984 (MoGene1.0st)   10341946 (MoGene1.0st)   10342565 (MoGene1.0st)   10342944 (MoGene1.0st)   1415694_at (Mouse Genome 430 2.0 Array)   1425106_a_at (Mouse Genome 430 2.0 Array)   1434813_x_at (Mouse Genome 430 2.0 Array)   1437832_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105474
Ensembl peptide - ENSMUSP00000124649
Ensembl peptide - ENSMUSP00000125102
Ensembl peptide - ENSMUSP00000125320
Ensembl peptide - ENSMUSP00000124625
NCBI entrez gene - 22375     See in Manteia.
MGI - MGI:104630
RefSeq - XM_006515819
RefSeq - NM_001164314
RefSeq - NM_001164488
RefSeq - NM_011710
RefSeq Peptide - NP_035840
RefSeq Peptide - NP_001157786
RefSeq Peptide - NP_001157960
swissprot - E0CXQ4
swissprot - E0CXX4
swissprot - P32921
swissprot - Q3U6U7
Ensembl - ENSMUSG00000021266
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 warsENSDARG00000100954Danio rerio
 WARSENSGALG00000011228Gallus gallus
 WARSENSG00000140105Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000738  WHEP-TRS domain
 IPR001412  Aminoacyl-tRNA synthetase, class I, conserved site
 IPR002305  Aminoacyl-tRNA synthetase, class Ic
 IPR002306  Tryptophan-tRNA ligase
 IPR009068  S15/NS1, RNA-binding
 IPR014729  Rossmann-like alpha/beta/alpha sandwich fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006418 tRNA aminoacylation for protein translation IEA
 biological_processGO:0006436 tryptophanyl-tRNA aminoacylation IDA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010835 regulation of protein ADP-ribosylation IEA
 biological_processGO:0031334 positive regulation of protein complex assembly IEA
 biological_processGO:0045765 regulation of angiogenesis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004812 aminoacyl-tRNA ligase activity IEA
 molecular_functionGO:0004830 tryptophan-tRNA ligase activity IMP
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0019210 kinase inhibitor activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0010067 increased red blood cell distribution width "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]
Show

Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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