Manteia

ENSG00000140105

Homo sapiens

Features

Gene ID:	ENSG00000140105

Biological name :	WARS

Synonyms :	P23381 / tryptophanyl-tRNA synthetase / WARS

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	14
Strand:	-1
Band:	q32.2
Gene start:	100333788
Gene end:	100376805

Corresponding Affymetrix probe sets:	200628_s_at (Human Genome U133 Plus 2.0 Array) 200629_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000450978 Ensembl peptide - ENSP00000451679 Ensembl peptide - ENSP00000451716 Ensembl peptide - ENSP00000451777 Ensembl peptide - ENSP00000451887 Ensembl peptide - ENSP00000451891 Ensembl peptide - ENSP00000451894 Ensembl peptide - ENSP00000451906 Ensembl peptide - ENSP00000451922 Ensembl peptide - ENSP00000451953 Ensembl peptide - ENSP00000452358 Ensembl peptide - ENSP00000452379 Ensembl peptide - ENSP00000452519 Ensembl peptide - ENSP00000452550 Ensembl peptide - ENSP00000487316 Ensembl peptide - ENSP00000339485 Ensembl peptide - ENSP00000347495 Ensembl peptide - ENSP00000351481 Ensembl peptide - ENSP00000376620 Ensembl peptide - ENSP00000450427 Ensembl peptide - ENSP00000450500 Ensembl peptide - ENSP00000450563 Ensembl peptide - ENSP00000450623 Ensembl peptide - ENSP00000450934 Ensembl peptide - ENSP00000451027 Ensembl peptide - ENSP00000451251 Ensembl peptide - ENSP00000451349 Ensembl peptide - ENSP00000451377 Ensembl peptide - ENSP00000451402 Ensembl peptide - ENSP00000451460 Ensembl peptide - ENSP00000451469 Ensembl peptide - ENSP00000451490 Ensembl peptide - ENSP00000451544 Ensembl peptide - ENSP00000451599 NCBI entrez gene - 7453 See in Manteia. OMIM - 191050 RefSeq - XM_017021628 RefSeq - XM_017021627 RefSeq - XM_011537136 RefSeq - XM_011537135 RefSeq - XM_011537133 RefSeq - XM_006720249 RefSeq - XM_005268044 RefSeq - NM_213646 RefSeq - NM_004184 RefSeq - NM_213645 RefSeq - NM_173701 RefSeq - XM_017021629 RefSeq Peptide - NP_998811 RefSeq Peptide - NP_004175 RefSeq Peptide - NP_776049 RefSeq Peptide - NP_998810 swissprot - G3V4A3 swissprot - G3V4C7 swissprot - G3V4N0 swissprot - G3V4N8 swissprot - G3V4Q0 swissprot - G3V4S4 swissprot - G3V5H5 swissprot - G3V5U1 swissprot - G3V5W1 swissprot - H0YJP3 swissprot - G3V3X0 swissprot - G3V3S7 swissprot - G3V3R3 swissprot - G3V3P2 swissprot - G3V277 swissprot - G3V227 swissprot - A0A024R6K8 swissprot - G3V3H8 swissprot - P23381 swissprot - P78534 swissprot - G3V339 swissprot - G3V313 swissprot - G3V2Y7 swissprot - G3V2F2 swissprot - G3V2C0 swissprot - G3V3Y5 swissprot - G3V423 swissprot - G3V456 Ensembl - ENSG00000140105

Related genetic diseases (OMIM):	617721 - Neuronopathy, distal hereditary motor, type IX, 617721

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
wars	ENSDARG00000100954	Danio rerio
WARS	ENSGALG00000011228	Gallus gallus
Wars	ENSMUSG00000021266	Mus musculus

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR000738	WHEP-TRS domain
IPR001412	Aminoacyl-tRNA synthetase, class I, conserved site
IPR002305	Aminoacyl-tRNA synthetase, class Ic
IPR002306	Tryptophan-tRNA ligase
IPR009068	S15/NS1, RNA-binding
IPR014729	Rossmann-like alpha/beta/alpha sandwich fold

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001525	angiogenesis	IEA
biological_process	GO:0001933	negative regulation of protein phosphorylation	IDA
biological_process	GO:0006412	translation	IEA
biological_process	GO:0006418	tRNA aminoacylation for protein translation	IEA
biological_process	GO:0006436	tryptophanyl-tRNA aminoacylation	IEA
biological_process	GO:0006469	negative regulation of protein kinase activity	IDA
biological_process	GO:0008285	negative regulation of cell proliferation	TAS
biological_process	GO:0010628	positive regulation of gene expression	IDA
biological_process	GO:0010835	regulation of protein ADP-ribosylation	IDA
biological_process	GO:0031334	positive regulation of protein complex assembly	IMP
biological_process	GO:0045765	regulation of angiogenesis	IDA
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	IDA
cellular_component	GO:0032991	protein-containing complex	IMP
cellular_component	GO:0070062	extracellular exosome	HDA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0004812	aminoacyl-tRNA ligase activity	IEA
molecular_function	GO:0004830	tryptophan-tRNA ligase activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016874	ligase activity	IEA
molecular_function	GO:0019210	kinase inhibitor activity	IDA
molecular_function	GO:0019901	protein kinase binding	IPI
molecular_function	GO:0019904	protein domain specific binding	IPI
molecular_function	GO:0042803	protein homodimerization activity	IDA

Pathways (from Reactome)

Pathway description

Cytosolic tRNA aminoacylation

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000140105	WARS / P23381 / tryptophanyl-tRNA synthetase	/ complex

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr