ENSMUSG00000021427


Mus musculus

Features
Gene ID: ENSMUSG00000021427
  
Biological name :Ssr1
  
Synonyms : Q9CY50 / Ssr1 / Translocon-associated protein subunit alpha
  
Possible biological names infered from orthology : P43307 / signal sequence receptor subunit 1
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A3.3
Gene start: 37966605
Gene end: 37994217
  
Corresponding Affymetrix probe sets: 10408709 (MoGene1.0st)   1417763_at (Mouse Genome 430 2.0 Array)   1417764_at (Mouse Genome 430 2.0 Array)   1441327_a_at (Mouse Genome 430 2.0 Array)   1448843_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021864
Ensembl peptide - ENSMUSP00000153346
Ensembl peptide - ENSMUSP00000153120
Ensembl peptide - ENSMUSP00000152975
NCBI entrez gene - 107513     See in Manteia.
MGI - MGI:105082
RefSeq - XM_006516524
RefSeq - NM_025965
RefSeq Peptide - NP_080241
swissprot - A0A286YCT4
swissprot - A0A286YDB7
swissprot - Q9CY50
swissprot - A0A286YCG8
Ensembl - ENSMUSG00000021427
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ssr1ENSDARG00000101627Danio rerio
 SSR1ENSGALG00000012798Gallus gallus
 SSR1ENSG00000124783Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005595  Translocon-associated protein (TRAP), alpha subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006613 cotranslational protein targeting to membrane IBA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
Show

Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0002746 abnormal semilunar valve morphology "malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728]
Show

Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0008825 abnormal cardiac epithelial to mesenchymal transition "anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760]
Show

Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0010454 abnormal truncus arteriosis septation "anomaly in the process of dividing the common arterial trunk arising out of both heart ventricles to divide into the aorta and pulmonary artery during development" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0010645 failure of conotruncal ridge closure "failure of the conotruncal ridges to develop from the conotruncus, meet at the midline and fuse to form the conotruncal septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0010651 aorticopulmonary septal defect "an abnormal communication in the septum between the aorta and pulmonary artery, resulting from incomplete separation of the common tube of the truncus arteriosus and the aorticopulmonary trunk" [http://emedicine.medscape.com]
Show

Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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