ENSMUSG00000021539


Mus musculus

Features
Gene ID: ENSMUSG00000021539
  
Biological name :Lect2
  
Synonyms : Lect2 / leukocyte cell derived chemotaxin 2
  
Possible biological names infered from orthology : O14960
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B1
Gene start: 56542464
Gene end: 56548502
  
Corresponding Affymetrix probe sets: 10409592 (MoGene1.0st)   1449492_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000060495
Ensembl peptide - ENSMUSP00000153699
NCBI entrez gene - 16841     See in Manteia.
MGI - MGI:1278342
RefSeq - NM_010702
RefSeq Peptide - NP_034832
swissprot - A0A286YE52
swissprot - A0A0R4J0R8
Ensembl - ENSMUSG00000021539
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lect2lENSDARG00000033227Danio rerio
 si:ch211-132p1.3ENSDARG00000090889Danio rerio
 si:ch211-132p1.4ENSDARG00000086483Danio rerio
 LECT2ENSGALG00000006323Gallus gallus
 LECT2ENSG00000145826Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008663  Leukocyte cell-derived chemotaxin 2
 IPR016047  Peptidase M23
 IPR017381  Leukocyte cell-derived chemotaxin 2, chordata


Gene Ontology (GO)
TypeGO IDTermEv.Code
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

 MP:0001570 abnormal circulating enzyme level "aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rs1tm1Web/Y
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco

 MP:0002018 malignant tumors "higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427]
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rs1tm1Web/Y
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Rs1tm1Web/Y
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rs1tm1Web/Y
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rs1tm1Web/Y
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008039 increased NK T cell number "greater number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco

 MP:0008042 abnormal NK T cell physiology "any functional anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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