ENSMUSG00000021681


Mus musculus

Features
Gene ID: ENSMUSG00000021681
  
Biological name :Aggf1
  
Synonyms : Aggf1 / Angiogenic factor with G patch and FHA domains 1 / Q7TN31
  
Possible biological names infered from orthology : AC008581.2 / Q8N302
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D1
Gene start: 95350683
Gene end: 95375352
  
Corresponding Affymetrix probe sets: 10411199 (MoGene1.0st)   1425354_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022189
NCBI entrez gene - 66549     See in Manteia.
MGI - MGI:1913799
RefSeq - NM_025630
RefSeq Peptide - NP_079906
swissprot - Q7TN31
Ensembl - ENSMUSG00000021681
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aggf1ENSDARG00000060109Danio rerio
 ENSGALG00000004311Gallus gallus
 AC008581.2ENSG00000285000Homo sapiens
 AGGF1ENSG00000164252Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000253  Forkhead-associated (FHA) domain
 IPR000467  G-patch domain
 IPR008984  SMAD/FHA domain superfamily
 IPR035624  AGGF1, OCRE domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001570 vasculogenesis IBA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation ISS
 biological_processGO:0007155 cell adhesion ISO
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045766 positive regulation of angiogenesis IBA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Glt8d2tm1Lex/Glt8d2tm1Lex
Genetic Background: B6;129S5-Glt8d2tm1Lex/Mmucd

Allelic Composition: Aggf1tm1Qkw/Aggf1+
Genetic Background: involves: 129 * C57BL/6

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
Show

Allelic Composition: Glt8d2tm1Lex/Glt8d2tm1Lex
Genetic Background: B6;129S5-Glt8d2tm1Lex/Mmucd

Allelic Composition: Aggf1tm1Qkw/Aggf1+
Genetic Background: involves: 129 * C57BL/6

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: Glt8d2tm1Lex/Glt8d2tm1Lex
Genetic Background: B6;129S5-Glt8d2tm1Lex/Mmucd

Allelic Composition: Aggf1tm1Qkw/Aggf1+
Genetic Background: involves: 129 * C57BL/6

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Glt8d2tm1Lex/Glt8d2tm1Lex
Genetic Background: B6;129S5-Glt8d2tm1Lex/Mmucd

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Glt8d2tm1Lex/Glt8d2tm1Lex
Genetic Background: B6;129S5-Glt8d2tm1Lex/Mmucd

Allelic Composition: Aggf1tm1Qkw/Aggf1+
Genetic Background: involves: 129 * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Glt8d2tm1Lex/Glt8d2tm1Lex
Genetic Background: B6;129S5-Glt8d2tm1Lex/Mmucd

 MP:0002899 fatigue "easily exhausted due to mental or physical exertion" [hdene:Howard Dene , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Glt8d2tm1Lex/Glt8d2tm1Lex
Genetic Background: B6;129S5-Glt8d2tm1Lex/Mmucd

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Glt8d2tm1Lex/Glt8d2tm1Lex
Genetic Background: B6;129S5-Glt8d2tm1Lex/Mmucd

Allelic Composition: Aggf1tm1Qkw/Aggf1+
Genetic Background: involves: 129 * C57BL/6

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Glt8d2tm1Lex/Glt8d2tm1Lex
Genetic Background: B6;129S5-Glt8d2tm1Lex/Mmucd

Allelic Composition: Aggf1tm1Qkw/Aggf1+
Genetic Background: involves: 129 * C57BL/6

 MP:0004003 abnormal vascular endothelial cell physiology "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Glt8d2tm1Lex/Glt8d2tm1Lex
Genetic Background: B6;129S5-Glt8d2tm1Lex/Mmucd

Allelic Composition: Aggf1tm1Qkw/Aggf1+
Genetic Background: involves: 129 * C57BL/6

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Glt8d2tm1Lex/Glt8d2tm1Lex
Genetic Background: B6;129S5-Glt8d2tm1Lex/Mmucd

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Glt8d2tm1Lex/Glt8d2tm1Lex
Genetic Background: B6;129S5-Glt8d2tm1Lex/Mmucd

 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Glt8d2tm1Lex/Glt8d2tm1Lex
Genetic Background: B6;129S5-Glt8d2tm1Lex/Mmucd

Allelic Composition: Aggf1tm1Qkw/Aggf1+
Genetic Background: involves: 129 * C57BL/6

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Glt8d2tm1Lex/Glt8d2tm1Lex
Genetic Background: B6;129S5-Glt8d2tm1Lex/Mmucd

Allelic Composition: Aggf1tm1Qkw/Aggf1+
Genetic Background: involves: 129 * C57BL/6

 MP:0011134 decreased lung endothelial cell migration "reduced or slower movement of endothelial cells or their precursors to the appropriate location in the pulmonary vasculature" [MGI:csmith]
Show

Allelic Composition: Glt8d2tm1Lex/Glt8d2tm1Lex
Genetic Background: B6;129S5-Glt8d2tm1Lex/Mmucd

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Glt8d2tm1Lex/Glt8d2tm1Lex
Genetic Background: B6;129S5-Glt8d2tm1Lex/Mmucd

Allelic Composition: Aggf1tm1Qkw/Aggf1tm1Qkw
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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