Manteia

ID	Phenotype	Definition	Genetic BG
MP:0000160	kyphosis	"forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0000414	alopecia	"absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]	Show Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: B6.129S4-Ndufs4^tm1.1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: B6.Cg-Tg(Nes-cre)1Kln Ndufs4^tm1Rpa
MP:0000416	sparse fur	"fur that is significantly less dense" [J:46854]	Show Allelic Composition: Aire^tm1.1Doi/Aire^tm1.1Doi Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD
MP:0000418	patchy hair	"uneven spots of hair growth on the body" [J:26975]	Show Allelic Composition: Ndufs4^fky/Ndufs4^fky Genetic Background: C57BL/6-Ndufs4^fky
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0000846	abnormal medulla oblongata	"anomaly in the most caudal region of the brainstem that lies directly rostral to the spinal cord; includes regions responsible for autonomic functions such as digestion, breathing and control of heart rate" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: B6.129S4-Ndufs4^tm1.1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: B6.Cg-Tg(Nes-cre)1Kln Ndufs4^tm1Rpa
MP:0000876	Purkinje cell degeneration	"a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]	Show Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0001059	optic nerve atrophy	"wasting of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0001259	abnormal body weight	"anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa Genetic Background: B6.129S4-Ndufs4^tm1Rpa
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Aire^tm1.1Doi/Aire^tm1.1Doi Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Ndufs4^fky/Ndufs4^fky Genetic Background: C57BL/6-Ndufs4^fky Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: B6.129S4-Ndufs4^tm1.1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: B6.Cg-Tg(Nes-cre)1Kln Ndufs4^tm1Rpa
MP:0001304	cataracts	"complete or partial opacity of the lens" [J:65031]	Show Allelic Composition: Aire^tm1.1Doi/Aire^tm1.1Doi Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0001344	blepharoptosis	"ptosis, drooping eyelids " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:24414]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Aire^tm1.1Doi/Aire^tm1.1Doi Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: B6.129S4-Ndufs4^tm1.1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: B6.Cg-Tg(Nes-cre)1Kln Ndufs4^tm1Rpa
MP:0001394	circling	"repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Ndufs4^fky/Ndufs4^fky Genetic Background: C57BL/6-Ndufs4^fky
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0001405	impaired coordination	"reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa Genetic Background: B6.129S4-Ndufs4^tm1Rpa
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0001442	decreased grooming behavior	"reduced amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0001447	abnormal nest building behavior	"deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]	Show Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0001489	decreased startle reflex	"greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]	Show Allelic Composition: Aire^tm1.1Doi/Aire^tm1.1Doi Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0001504	abnormal posture	"atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0001505	hunched posture	"stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]	Show Allelic Composition: Aire^tm1.1Doi/Aire^tm1.1Doi Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD
MP:0001512	trunk curl	"posture of the trunk in a curled position" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0001513	limb grasping	"mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Aire^tm1.1Doi/Aire^tm1.1Doi Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Ndufs4^fky/Ndufs4^fky Genetic Background: C57BL/6-Ndufs4^fky
MP:0001516	abnormal motor coordination/ balance	"altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Aire^tm1.1Doi/Aire^tm1.1Doi Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0001522	impaired swimming	"reduced ability or inability to swim" [J:45446, J:39081]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0001523	impaired righting response	"reduced ability or greater amount of time needed to recover from supine position" [J:25565]	Show Allelic Composition: Aire^tm1.1Doi/Aire^tm1.1Doi Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0001525	impaired balance	"reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]	Show Allelic Composition: Aire^tm1.1Doi/Aire^tm1.1Doi Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Aire^tm1.1Doi/Aire^tm1.1Doi Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Ndufs4^fky/Ndufs4^fky Genetic Background: C57BL/6-Ndufs4^fky Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: B6.129S4-Ndufs4^tm1.1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: B6.Cg-Tg(Nes-cre)1Kln Ndufs4^tm1Rpa
MP:0001915	intracranial hemorrhage	"bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0001951	abnormal breathing	"irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: B6.129S4-Ndufs4^tm1.1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: B6.Cg-Tg(Nes-cre)1Kln Ndufs4^tm1Rpa
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: B6.129S4-Ndufs4^tm1.1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: B6.Cg-Tg(Nes-cre)1Kln Ndufs4^tm1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa Genetic Background: B6.129S4-Ndufs4^tm1Rpa
MP:0001957	apnea	"absence of breathing; sometimes episodic" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17384]	Show Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: B6.129S4-Ndufs4^tm1.1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: B6.Cg-Tg(Nes-cre)1Kln Ndufs4^tm1Rpa
MP:0002001	blindness	"loss of the sense of sight" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Aire^tm1.1Doi/Aire^tm1.1Doi Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD
MP:0002064	seizures	"sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0002066	abnormal motor capabilities/coordination/movement	"altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Slc14a2^tm1Raf/Slc14a2^tm1Raf Genetic Background: B6.129S6-Slc14a2^tm1Raf
MP:0002067	abnormal sensory capabilities/reflexes/nociception	"inability or altered ability to respond to a sensory stimulus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Aire^tm1.1Doi/Aire^tm1.1Doi Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^fky/Ndufs4^fky Genetic Background: C57BL/6-Ndufs4^fky Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: B6.129S4-Ndufs4^tm1.1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: B6.Cg-Tg(Nes-cre)1Kln Ndufs4^tm1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa Genetic Background: B6.129S4-Ndufs4^tm1Rpa
MP:0002090	abnormal vision	"inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Aire^tm1.1Doi/Aire^tm1.1Doi Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD
MP:0002183	gliosis	"increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: B6.129S4-Ndufs4^tm1.1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: B6.Cg-Tg(Nes-cre)1Kln Ndufs4^tm1Rpa
MP:0002229	CNS neurodegeneration	"a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: B6.129S4-Ndufs4^tm1.1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: B6.Cg-Tg(Nes-cre)1Kln Ndufs4^tm1Rpa
MP:0002338	abnormal pulmonary ventilation	"anomaly in the total volume of gas per minute inspired or expired " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: B6.129S4-Ndufs4^tm1.1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: B6.Cg-Tg(Nes-cre)1Kln Ndufs4^tm1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa Genetic Background: B6.129S4-Ndufs4^tm1Rpa
MP:0002572	abnormal emotion/affect behavior	"altered response in tests for emotional related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0002654	spongiform encephalopathy	"a neurodegenerative state characterized by the appearance of large vacuolated areas in the brain cells, resembling a sponge" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0002882	abnormal neuron	"anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0003224	neuron degeneration	"a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0003354	astrocytosis	"a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0003382	straub tail	"condition in which an animal carries its tail in an erect (vertical or nearly vertical) position; often seen upon opioid and other drug treatment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0003674	oxidative stress	"condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0003979	increased circulating carnitine level	"greater than normal blood concentration of this quaternary ammonium amino acid derivative involved in transport of fatty acids across the mitochondrial membrane" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Ndufs4^fky/Ndufs4^fky Genetic Background: C57BL/6-Ndufs4^fky
MP:0003997	tonic-clonic seizures	"increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
MP:0004142	abnormal muscle tone	"anomaly in the resting tautness or laxity of a muscle, normally somewhere in the middle of the range between total contraction and total relaxation" [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0004144	hypotonia	"decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness" [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: B6.129S4-Ndufs4^tm1.1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: B6.Cg-Tg(Nes-cre)1Kln Ndufs4^tm1Rpa
MP:0004811	abnormal neuron physiology	"anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0004950	abnormal brain vasculature	"any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0005114	premature hair loss	"release of fur at an earlier than expected time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0005191	head tilt	"condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ndufs4^fky/Ndufs4^fky Genetic Background: C57BL/6-Ndufs4^fky
MP:0005202	lethargy	"mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Aire^tm1.1Doi/Aire^tm1.1Doi Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: B6.129S4-Ndufs4^tm1.1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: B6.Cg-Tg(Nes-cre)1Kln Ndufs4^tm1Rpa
MP:0005311	abnormal circulating amino acid level	"aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]	Show Allelic Composition: Ndufs4^fky/Ndufs4^fky Genetic Background: C57BL/6-Ndufs4^fky
MP:0005333	decreased heart rate	"fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: B6.129S4-Ndufs4^tm1.1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: B6.Cg-Tg(Nes-cre)1Kln Ndufs4^tm1Rpa
MP:0005356	positive geotaxis	"mice, when placed on a downward on a slanting grid, walk down without turning around, or exhibit a delay in turning around, whereas wild type mice will always turn around and walk upward" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:79604]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0005498	hyporesponsive to tactile stimuli	"reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0005507	tail dragging	"pulling the tail along with difficulty or effort; may be due to paralysis or weakness" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0005534	decreased body temperature	"less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Aire^tm1.1Doi/Aire^tm1.1Doi Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: B6.129S4-Ndufs4^tm1.1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: B6.Cg-Tg(Nes-cre)1Kln Ndufs4^tm1Rpa
MP:0005551	abnormal eye electrophysiology	"abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]	Show Allelic Composition: Aire^tm1.1Doi/Aire^tm1.1Doi Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD
MP:0005574	decreased breathing frequency	"fewer than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]	Show Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: B6.129S4-Ndufs4^tm1.1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: B6.Cg-Tg(Nes-cre)1Kln Ndufs4^tm1Rpa
MP:0005584	abnormal enzyme/coenzyme activity	"altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ptprg^tm1.1Lex/Ptprg^tm1.1Lex Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0005604	hyperekplexia	"disorder characterized by pathologic startle responses, protective reactions to unanticipated, potentially threatening, stimuli of any type, particularly auditory" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0005656	decreased aggression	"when compared to controls, subjects exhibit less than the normal level of domineering, assaultive posture and/or hostile physical action" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0006051	brainstem hemorrhage	"bleeding into the brain stem" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0008025	brain vacuoles	"the abnormal presence of cavities or fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: B6.129S4-Ndufs4^tm1.1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: B6.Cg-Tg(Nes-cre)1Kln Ndufs4^tm1Rpa
MP:0008918	microgliosis	"a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: B6.129S4-Ndufs4^tm1.1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: B6.Cg-Tg(Nes-cre)1Kln Ndufs4^tm1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa Genetic Background: B6.129S4-Ndufs4^tm1Rpa
MP:0009358	environmentally induced seizures	"relatively mild but sudden stimulation due to changes in ambient habitat including lighting, sounds, touching, and/ or moving cage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0009642	abnormal blood homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: B6.129S4-Ndufs4^tm1.1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: B6.Cg-Tg(Nes-cre)1Kln Ndufs4^tm1Rpa
MP:0009931	abnormal skin appearance	"skin that looks different from the usual state" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0009947	abnormal olfactory bulb external plexiform layer morphology	"any structural anomaly of the part of the olfactory bulb, lying superior to the mitral cell layer and inferior to the glomerular layer, which is mostly neuropil composed almost entirely of mitral and tufted cell dendrites, granule cell dendrites and their synaptic inputs" [NLX:nlx_96 "NeuroLex.org"]	Show Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: B6.129S4-Ndufs4^tm1.1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: B6.Cg-Tg(Nes-cre)1Kln Ndufs4^tm1Rpa
MP:0009964	abnormal cerebellum lobule morphology	"any structural anomaly of the ten gyri of the cerebellar cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: B6.129S4-Ndufs4^tm1.1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: B6.Cg-Tg(Nes-cre)1Kln Ndufs4^tm1Rpa
MP:0009983	abnormal cerebellum fastigial nucleus morphology	"any structural anomaly of the most medial of the cerebellar nuclei; it receives its afferent input from Purkinje cells of the flocculonodular lobe and the vermis, and most of its efferent connections travel via the inferior cerebellar peduncle to the vestibular nuclei and to the medullary reticular formation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: B6.129S4-Ndufs4^tm1.1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: B6.Cg-Tg(Nes-cre)1Kln Ndufs4^tm1Rpa
MP:0010047	axonal spheroids	"focal 10-50 micron diameter swellings of axons, which are sometimes, but not always, terminal endbulbs, and are filled with disorganized neurofilaments, tubules, organelles or multi-lamellar inclusions" [PMID:15644421]	Show Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0010323	retropulsion	"a tendency to step or walk backwards" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0010746	abnormal pre-Botzinger complex physiology	"any functional anomaly of the group of interneurons within the medulla oblongata s ventral respiratory group that are important for the generation of ventilatory (inspiratory) rhythmogenesis" [PMID:18826652]	Show Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: B6.129S4-Ndufs4^tm1.1Rpa Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: B6.Cg-Tg(Nes-cre)1Kln Ndufs4^tm1Rpa
MP:0010955	abnormal respiratory electron transport chain	"anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1Capt/Ndufs4⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac
MP:0010956	abnormal mitochondrial ATP synthesis coupled electron transport	"anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Aire^tm1.1Doi/Aire^tm1.1Doi Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0011635	abnormal mitochondrial crista morphology	"Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061]	Show Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor
MP:0020351	decreased vocalization	"decrease in the production of vocal sound" [ORCID: orcid.org/0000-0003-4606-0597, PMID:26621702]	Show Allelic Composition: Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Ndufs4^tm1.1Rpa/Ndufs4^tm1.1Rpa Genetic Background: involves: 129S4/SvJaeSor

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr

ENSMUSG00000021764