ENSMUSG00000021890


Mus musculus

Features
Gene ID: ENSMUSG00000021890
  
Biological name :Eaf1
  
Synonyms : Eaf1 / ELL-associated factor 1 / Q9D4C5
  
Possible biological names infered from orthology : Q96JC9
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: B
Gene start: 31494399
Gene end: 31509858
  
Corresponding Affymetrix probe sets: 10413795 (MoGene1.0st)   1431065_at (Mouse Genome 430 2.0 Array)   1433555_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022446
NCBI entrez gene - 74427     See in Manteia.
MGI - MGI:1921677
RefSeq - NM_028932
RefSeq Peptide - NP_083208
swissprot - Q9D4C5
Ensembl - ENSMUSG00000021890
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eaf1ENSDARG00000070795Danio rerio
 EAF1ENSGALG00000033379Gallus gallus
 EAF1ENSG00000144597Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eaf2 / Q91ZD6 / ELL-associated factor 2 / Q96CJ1*ENSMUSG0000002283851


Protein motifs (from Interpro)
Interpro ID Name
 IPR019194  Transcription elognation factor Eaf, N-terminal
 IPR027093  EAF family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0008023 transcription elongation factor complex IEA
 cellular_componentGO:0015030 Cajal body IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0032783 ELL-EAF complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045171 intercellular bridge IEA
 molecular_functionGO:0008134 transcription factor binding ISO


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription Elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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