ENSMUSG00000021922


Mus musculus

Features
Gene ID: ENSMUSG00000021922
  
Biological name :Itih4
  
Synonyms : A6X935 / Inter alpha-trypsin inhibitor, heavy chain 4 / Itih4
  
Possible biological names infered from orthology : inter-alpha-trypsin inhibitor heavy chain family member 4 / Q14624
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: B
Gene start: 30886476
Gene end: 30902353
  
Corresponding Affymetrix probe sets: 10413615 (MoGene1.0st)   1431808_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006703
Ensembl peptide - ENSMUSP00000125920
Ensembl peptide - ENSMUSP00000112798
Ensembl peptide - ENSMUSP00000077580
NCBI entrez gene - 16427     See in Manteia.
MGI - MGI:109536
RefSeq - NM_001159299
RefSeq - NM_018746
RefSeq - NM_001289633
RefSeq - NM_001289632
RefSeq Peptide - NP_061216
RefSeq Peptide - NP_001152771
RefSeq Peptide - NP_001276561
RefSeq Peptide - NP_001276562
swissprot - E9Q5L2
swissprot - A0A0R4J1N1
swissprot - A6X935
swissprot - E9PVD2
Ensembl - ENSMUSG00000021922
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itih3bENSDARG00000102722Danio rerio
 zgc:112265ENSDARG00000100406Danio rerio
 ITIH4ENSG00000055955Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itih3 / Q61704 / Inter-alpha-trypsin inhibitor heavy chain H3 / Q06033* / inter-alpha-trypsin inhibitor heavy chain 3*ENSMUSG0000000652239
Itih1 / Q61702 / Inter-alpha-trypsin inhibitor heavy chain H1 / P19827* / inter-alpha-trypsin inhibitor heavy chain 1*ENSMUSG0000000652934
Itih2 / inter-alpha trypsin inhibitor, heavy chain 2 / P19823*ENSMUSG0000003725430
Itih5 / Q8BJD1 / Inter-alpha-trypsin inhibitor heavy chain H5 / inter-alpha-trypsin inhibitor heavy chain family member 5*ENSMUSG0000002578029


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR010600  Inter-alpha-trypsin inhibitor heavy chain, C-terminal
 IPR013694  VIT domain
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006953 acute-phase response IEA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0030212 hyaluronan metabolic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itih4tm1Mish/Itih4tm1Mish,Sptbn1tm1Mish/Sptbn1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * NIH Black Swiss

 MP:0004001 decreased hepatocyte proliferation "reduced growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cyp11a1tm2Bcc/Cyp11a1tm2Bcc
Genetic Background: Not Specified

 MP:0008891 decreased hepatocyte apoptosis "reduction in the number of hepatocytes undergoing programmed cell death" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Itih4tm1Mish/Itih4tm1Mish,Sptbn1tm1Mish/Sptbn1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * NIH Black Swiss

 MP:0010266 decreased liver tumor incidence "less than the expected number of neoplams in the liver, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itih4tm1Mish/Itih4tm1Mish,Sptbn1tm1Mish/Sptbn1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * NIH Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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