ENSMUSG00000022033


Mus musculus

Features
Gene ID: ENSMUSG00000022033
  
Biological name :Pbk
  
Synonyms : Lymphokine-activated killer T-cell-originated protein kinase / Pbk / Q9JJ78
  
Possible biological names infered from orthology : PDZ binding kinase / Q96KB5
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: D1
Gene start: 65805837
Gene end: 65817822
  
Corresponding Affymetrix probe sets: 10416037 (MoGene1.0st)   1448627_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114484
Ensembl peptide - ENSMUSP00000022612
NCBI entrez gene - 52033     See in Manteia.
MGI - MGI:1289156
RefSeq - NM_023209
RefSeq - XM_006519257
RefSeq Peptide - NP_075698
swissprot - D3YVF2
swissprot - Q9JJ78
Ensembl - ENSMUSG00000022033
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pbkENSDARG00000007221Danio rerio
 PBKENSGALG00000016582Gallus gallus
 PBKENSG00000168078Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR034368  Lymphokine-activated killer T-cell-originated protein kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation ISO
 biological_processGO:0018107 peptidyl-threonine phosphorylation ISO
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0032873 negative regulation of stress-activated MAPK cascade IMP
 biological_processGO:0034644 cellular response to UV IMP
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J

 MP:0009932 skin fibrosis "invasion of fibrous connective tissue into the skin, often resulting from inflammation or injury" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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