ENSMUSG00000022136


Mus musculus

Features
Gene ID: ENSMUSG00000022136
  
Biological name :Dnajc3
  
Synonyms : Dnajc3 / DnaJ homolog subfamily C member 3 / Q91YW3
  
Possible biological names infered from orthology : DnaJ heat shock protein family (Hsp40) member C3 / Q13217
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: E4
Gene start: 118937976
Gene end: 118981697
  
Corresponding Affymetrix probe sets: 10417013 (MoGene1.0st)   10417034 (MoGene1.0st)   1419162_s_at (Mouse Genome 430 2.0 Array)   1419163_s_at (Mouse Genome 430 2.0 Array)   1433887_at (Mouse Genome 430 2.0 Array)   1449372_at (Mouse Genome 430 2.0 Array)   1449373_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022734
NCBI entrez gene - 100037258     See in Manteia.
MGI - MGI:107373
RefSeq - NM_008929
RefSeq Peptide - NP_032955
swissprot - Q3UFV9
swissprot - Q91YW3
Ensembl - ENSMUSG00000022136
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnajc3aENSDARG00000041110Danio rerio
 DNAJC3ENSGALG00000016894Gallus gallus
 DNAJC3ENSG00000102580Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dnajc7 / Q9QYI3 / DnaJ homolog subfamily C member 7 / Q99615* / DnaJ heat shock protein family (Hsp40) member C7*ENSMUSG0000001419526


Protein motifs (from Interpro)
Interpro ID Name
 IPR001623  DnaJ domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR018704  Tetratricopeptide repeat-like domain
 IPR019734  Tetratricopeptide repeat
 IPR036869  Chaperone J-domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity ISS
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IC
 biological_processGO:0036494 positive regulation of translation initiation in response to endoplasmic reticulum stress IDA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IDA
 biological_processGO:0070417 cellular response to cold IDA
 biological_processGO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen IDA
 cellular_componentGO:0005790 smooth endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031205 endoplasmic reticulum Sec complex IDA
 molecular_functionGO:0004860 protein kinase inhibitor activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0051087 chaperone binding IPI
 molecular_functionGO:0051787 misfolded protein binding IDA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Neutrophil degranulation
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Dnajc3tm8663Wcl/Dnajc3tm8663Wcl,Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Nr5a2tm1Lex/Nr5a2tm1Lex
Genetic Background: involves: 129

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Nr5a2tm1Lex/Nr5a2tm1Lex
Genetic Background: involves: 129

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nr5a2tm1Lex/Nr5a2tm1Lex
Genetic Background: involves: 129

 MP:0001759 increased urine glucose level "a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Nr5a2tm1Lex/Nr5a2tm1Lex
Genetic Background: involves: 129

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nr5a2tm1Lex/Nr5a2tm1Lex
Genetic Background: involves: 129

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr5a2tm1Lex/Nr5a2tm1Lex
Genetic Background: involves: 129

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nr5a2tm1Lex/Nr5a2tm1Lex
Genetic Background: involves: 129

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nr5a2tm1Lex/Nr5a2tm1Lex
Genetic Background: involves: 129

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nr5a2tm1Lex/Nr5a2tm1Lex
Genetic Background: involves: 129

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nr5a2tm1Lex/Nr5a2tm1Lex
Genetic Background: involves: 129

 MP:0009114 decreased pancreatic beta cell mass "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr5a2tm1Lex/Nr5a2tm1Lex
Genetic Background: involves: 129

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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