ENSMUSG00000022216


Mus musculus

Features
Gene ID: ENSMUSG00000022216
  
Biological name :Psme1
  
Synonyms : P97371 / proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) / Psme1
  
Possible biological names infered from orthology : proteasome activator subunit 1 / Q06323
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: C3
Gene start: 55578123
Gene end: 55581529
  
Corresponding Affymetrix probe sets: 10415282 (MoGene1.0st)   1417056_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133791
Ensembl peptide - ENSMUSP00000133883
Ensembl peptide - ENSMUSP00000134735
Ensembl peptide - ENSMUSP00000087046
Ensembl peptide - ENSMUSP00000133366
Ensembl peptide - ENSMUSP00000133867
NCBI entrez gene - 19186     See in Manteia.
MGI - MGI:1096367
RefSeq - NM_011189
RefSeq Peptide - NP_035319
swissprot - Q5HZK3
swissprot - G3UWN9
swissprot - G3UXR1
swissprot - G3UXY0
swissprot - G3UXZ5
swissprot - G3X9K9
swissprot - P97371
Ensembl - ENSMUSG00000022216
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psme1ENSDARG00000002165Danio rerio
 PSME1ENSG00000092010Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Psme2 / P97372 / Proteasome activator complex subunit 2 / Q9UL46* / proteasome activator subunit 2*ENSMUSG0000007919746
P97372 / Psme2b / protease (prosome, macropain) activator subunit 2B / PSME2* / Q9UL46* / proteasome activator subunit 2*ENSMUSG0000007815346
Psme3 / P61290 / proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) / P61289* / proteasome activator subunit 3*ENSMUSG0000007865239


Protein motifs (from Interpro)
Interpro ID Name
 IPR003185  Proteasome activator PA28, N-terminal domain
 IPR003186  Proteasome activator PA28, C-terminal domain
 IPR009077  Proteasome activator PA28
 IPR036252  Proteasome activator superfamily
 IPR036996  Proteasome activator PA28, N-terminal domain superfamily
 IPR036997  Proteasome activator PA28, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010950 positive regulation of endopeptidase activity IEA
 biological_processGO:0019884 antigen processing and presentation of exogenous antigen IMP
 biological_processGO:0061136 regulation of proteasomal protein catabolic process IBA
 biological_processGO:2000045 regulation of G1/S transition of mitotic cell cycle IBA
 cellular_componentGO:0000502 proteasome complex IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0008537 proteasome activator complex IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0061133 endopeptidase activator activity IPI


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002166 altered tumor susceptibility/resistance "greater than or less than the average number of tumors, usually a specific type, arising in a given strain when compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mecp2tm1Hzo/Mecp2+
Genetic Background: 129S7/SvEvBrd-Mecp2tm1Hzo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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