ENSMUSG00000078652


Mus musculus

Features
Gene ID: ENSMUSG00000078652
  
Biological name :Psme3
  
Synonyms : P61290 / proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) / Psme3
  
Possible biological names infered from orthology : P61289 / proteasome activator subunit 3
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 101316213
Gene end: 101323537
  
Corresponding Affymetrix probe sets: 10381345 (MoGene1.0st)   1418078_at (Mouse Genome 430 2.0 Array)   1418079_at (Mouse Genome 430 2.0 Array)   1438509_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116996
Ensembl peptide - ENSMUSP00000118279
Ensembl peptide - ENSMUSP00000019470
NCBI entrez gene - 19192     See in Manteia.
MGI - MGI:1096366
RefSeq - NM_011192
RefSeq - XM_006532525
RefSeq Peptide - NP_035322
swissprot - A2A4J3
swissprot - P61290
swissprot - Q4FK54
swissprot - A2A4J1
Ensembl - ENSMUSG00000078652
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psme3ENSDARG00000012234Danio rerio
 PSME3ENSGALG00000002937Gallus gallus
 PSME3ENSG00000131467Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Psme1 / P97371 / proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) / Q06323* / proteasome activator subunit 1*ENSMUSG0000002221639
Psme2 / P97372 / Proteasome activator complex subunit 2 / Q9UL46* / proteasome activator subunit 2*ENSMUSG0000007919732
P97372 / Psme2b / protease (prosome, macropain) activator subunit 2B / PSME2* / Q9UL46* / proteasome activator subunit 2*ENSMUSG0000007815332


Protein motifs (from Interpro)
Interpro ID Name
 IPR003185  Proteasome activator PA28, N-terminal domain
 IPR003186  Proteasome activator PA28, C-terminal domain
 IPR009077  Proteasome activator PA28
 IPR036252  Proteasome activator superfamily
 IPR036996  Proteasome activator PA28, N-terminal domain superfamily
 IPR036997  Proteasome activator PA28, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010950 positive regulation of endopeptidase activity IEA
 biological_processGO:0061136 regulation of proteasomal protein catabolic process IEA
 biological_processGO:2000045 regulation of G1/S transition of mitotic cell cycle IBA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0000502 proteasome complex IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0008537 proteasome activator complex IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0061133 endopeptidase activator activity IEA
 molecular_functionGO:0097371 MDM2/MDM4 family protein binding IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fbxw7tm1Sje/Fbxw7tm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fbxw7tm1Sje/Fbxw7tm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fbxw7tm1Sje/Fbxw7tm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Fbxw7tm1Sje/Fbxw7tm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005399 increased susceptibility to fungal infection "greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fbxw7tm1Sje/Fbxw7tm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Fbxw7tm1Sje/Fbxw7tm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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