ENSMUSG00000022244


Mus musculus

Features
Gene ID: ENSMUSG00000022244
  
Biological name :Amacr
  
Synonyms : Alpha-methylacyl-CoA racemase / Amacr / O09174
  
Possible biological names infered from orthology : Q9UHK6
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: A1
Gene start: 10981756
Gene end: 10996626
  
Corresponding Affymetrix probe sets: 10423090 (MoGene1.0st)   1417208_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000066915
NCBI entrez gene - 17117     See in Manteia.
MGI - MGI:1098273
RefSeq - NM_008537
RefSeq - XM_011245338
RefSeq Peptide - NP_032563
swissprot - O09174
Ensembl - ENSMUSG00000022244
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 amacrENSDARG00000057435Danio rerio
 AMACRENSGALG00000003326Gallus gallus
 AMACRENSG00000242110Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sugct / Q7TNE1 / Succinate--hydroxymethylglutarate CoA-transferase / Q9HAC7* / succinyl-CoA:glutarate-CoA transferase*ENSMUSG0000005513727


Protein motifs (from Interpro)
Interpro ID Name
 IPR003673  CoA-transferase family III
 IPR023606  CoA-transferase family III domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006699 bile acid biosynthetic process IEA
 biological_processGO:0008206 bile acid metabolic process IEA
 biological_processGO:0008300 isoprenoid catabolic process TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005777 peroxisome ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0008111 alpha-methylacyl-CoA racemase activity TAS
 molecular_functionGO:0016853 isomerase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Beta-oxidation of pristanoyl-CoA
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000180 abnormal circulating cholesterol level "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

 MP:0004773 abnormal bile composition "any alteration in the chemical make up of the greenish-yellow fluid secreted by the liver; normally contains bile acids and salts such as sodium glycocholate and sodium taurocholate as well as cholesterol, biliverdin and bilirubin, mucus, fat, lecithin, and cells and cellular debris" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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