ENSMUSG00000022253


Mus musculus

Features
Gene ID: ENSMUSG00000022253
  
Biological name :Nadk2
  
Synonyms : Nadk2 / NAD kinase 2, mitochondrial / Q8C5H8
  
Possible biological names infered from orthology : Q4G0N4
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: A1
Gene start: 9071260
Gene end: 9110891
  
Corresponding Affymetrix probe sets: 10422962 (MoGene1.0st)   1437285_at (Mouse Genome 430 2.0 Array)   1437286_x_at (Mouse Genome 430 2.0 Array)   1437287_at (Mouse Genome 430 2.0 Array)   1453422_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000068318
Ensembl peptide - ENSMUSP00000098353
Ensembl peptide - ENSMUSP00000098354
Ensembl peptide - ENSMUSP00000140212
NCBI entrez gene - 68646     See in Manteia.
MGI - MGI:1915896
RefSeq - NM_001085410
RefSeq - NM_001040395
RefSeq - NM_001286253
RefSeq - NM_001286255
RefSeq Peptide - NP_001273182
RefSeq Peptide - NP_001035485
RefSeq Peptide - NP_001078879
RefSeq Peptide - NP_001273184
swissprot - Q8C5H8
swissprot - A0A087WQI8
swissprot - Z4YK42
Ensembl - ENSMUSG00000022253
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nadk2ENSDARG00000007181Danio rerio
 NADK2ENSGALG00000003558Gallus gallus
 NADK2ENSG00000152620Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002504  NAD kinase
 IPR012355  NAD kinase, eukaryotic
 IPR016064  NAD kinase/diacylglycerol kinase-like domain superfamily
 IPR017437  ATP-NAD kinase, PpnK-type, C-terminal
 IPR017438  Inorganic polyphosphate/ATP-NAD kinase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006741 NADP biosynthetic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019674 NAD metabolic process ISS
 cellular_componentGO:0005739 mitochondrion ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003951 NAD+ kinase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity ISS


Pathways (from Reactome)
Pathway description
Nicotinate metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmachctm1.1(NCOM)Mfgc/Mmachctm1.1(NCOM)Mfgc
Genetic Background: C57BL/6N-Mmachctm1.1(NCOM)Mfgc/Tcp

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmachctm1.1(NCOM)Mfgc/Mmachctm1.1(NCOM)Mfgc
Genetic Background: C57BL/6N-Mmachctm1.1(NCOM)Mfgc/Tcp

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mmachctm1.1(NCOM)Mfgc/Mmachctm1.1(NCOM)Mfgc
Genetic Background: C57BL/6N-Mmachctm1.1(NCOM)Mfgc/Tcp

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Fth1tm1.1Ruvi/Fth1tm1.1Ruvi,Ftl1tm1.1Ruvi/Ftl1tm1.1Ruvi
Genetic Background: involves: 129 * C57BL/6

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Fth1tm1.1Ruvi/Fth1tm1.1Ruvi,Ftl1tm1.1Ruvi/Ftl1tm1.1Ruvi
Genetic Background: involves: 129 * C57BL/6

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fth1tm1.1Ruvi/Fth1tm1.1Ruvi,Ftl1tm1.1Ruvi/Ftl1tm1.1Ruvi
Genetic Background: involves: 129 * C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Fth1tm1.1Ruvi/Fth1tm1.1Ruvi,Ftl1tm1.1Ruvi/Ftl1tm1.1Ruvi
Genetic Background: involves: 129 * C57BL/6

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Fth1tm1.1Ruvi/Fth1tm1.1Ruvi,Ftl1tm1.1Ruvi/Ftl1tm1.1Ruvi
Genetic Background: involves: 129 * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fth1tm1.1Ruvi/Fth1tm1.1Ruvi,Ftl1tm1.1Ruvi/Ftl1tm1.1Ruvi
Genetic Background: involves: 129 * C57BL/6

 MP:0003103 liver degeneration "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]
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Allelic Composition: Fth1tm1.1Ruvi/Fth1tm1.1Ruvi,Ftl1tm1.1Ruvi/Ftl1tm1.1Ruvi
Genetic Background: involves: 129 * C57BL/6

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Fth1tm1.1Ruvi/Fth1tm1.1Ruvi,Ftl1tm1.1Ruvi/Ftl1tm1.1Ruvi
Genetic Background: involves: 129 * C57BL/6

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fth1tm1.1Ruvi/Fth1tm1.1Ruvi,Ftl1tm1.1Ruvi/Ftl1tm1.1Ruvi
Genetic Background: involves: 129 * C57BL/6

 MP:0003979 increased circulating carnitine level "greater than normal blood concentration of this quaternary ammonium amino acid derivative involved in transport of fatty acids across the mitochondrial membrane" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Fth1tm1.1Ruvi/Fth1tm1.1Ruvi,Ftl1tm1.1Ruvi/Ftl1tm1.1Ruvi
Genetic Background: involves: 129 * C57BL/6

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fth1tm1.1Ruvi/Fth1tm1.1Ruvi,Ftl1tm1.1Ruvi/Ftl1tm1.1Ruvi
Genetic Background: involves: 129 * C57BL/6

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
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Allelic Composition: Fth1tm1.1Ruvi/Fth1tm1.1Ruvi,Ftl1tm1.1Ruvi/Ftl1tm1.1Ruvi
Genetic Background: involves: 129 * C57BL/6

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fth1tm1.1Ruvi/Fth1tm1.1Ruvi,Ftl1tm1.1Ruvi/Ftl1tm1.1Ruvi
Genetic Background: involves: 129 * C57BL/6

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Mmachctm1.1(NCOM)Mfgc/Mmachctm1.1(NCOM)Mfgc
Genetic Background: C57BL/6N-Mmachctm1.1(NCOM)Mfgc/Tcp

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fth1tm1.1Ruvi/Fth1tm1.1Ruvi,Ftl1tm1.1Ruvi/Ftl1tm1.1Ruvi
Genetic Background: involves: 129 * C57BL/6

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fth1tm1.1Ruvi/Fth1tm1.1Ruvi,Ftl1tm1.1Ruvi/Ftl1tm1.1Ruvi
Genetic Background: involves: 129 * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Myo18atm1b(KOMP)Wtsi/Myo18a+
Genetic Background: C57BL/6N-Myo18atm1b(KOMP)Wtsi/Ucd

 MP:0013023 decreased Ly6C high monocyte number "decrease in the number of monocytes that express high levels of Ly6C and low MHC class II that represent a subset of circulating inflammatory monocytes that are recruited to infected or inflamed tissues" [MGI:Annie_Speak]
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Allelic Composition: Mmachctm1.1(NCOM)Mfgc/Mmachctm1.1(NCOM)Mfgc
Genetic Background: C57BL/6N-Mmachctm1.1(NCOM)Mfgc/Tcp

 MP:0013026 decreased Ly6C low monocyte number "decrease in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes" [MGI:Annie_Speak]
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Allelic Composition: Mmachctm1.1(NCOM)Mfgc/Mmachctm1.1(NCOM)Mfgc
Genetic Background: C57BL/6N-Mmachctm1.1(NCOM)Mfgc/Tcp

 MP:0014172 decreased fatty acid oxidation 
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Allelic Composition: Fth1tm1.1Ruvi/Fth1tm1.1Ruvi,Ftl1tm1.1Ruvi/Ftl1tm1.1Ruvi
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022253 Nadk2 / Q8C5H8 / NAD kinase 2, mitochondrial / Q4G0N4*  / complex






 

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