ENSMUSG00000022295


Mus musculus

Features
Gene ID: ENSMUSG00000022295
  
Biological name :Atp6v1c1
  
Synonyms : Atp6v1c1 / ATPase, H+ transporting, lysosomal V1 subunit C1 / Q9Z1G3
  
Possible biological names infered from orthology : ATPase H+ transporting V1 subunit C1 / P21283
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: B3.1
Gene start: 38661933
Gene end: 38692446
  
Corresponding Affymetrix probe sets: 10423805 (MoGene1.0st)   1419544_at (Mouse Genome 430 2.0 Array)   1419545_a_at (Mouse Genome 430 2.0 Array)   1419546_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022904
Ensembl peptide - ENSMUSP00000153731
Ensembl peptide - ENSMUSP00000154133
NCBI entrez gene - 66335     See in Manteia.
MGI - MGI:1913585
RefSeq - NM_025494
RefSeq Peptide - NP_079770
swissprot - Q9Z1G3
Ensembl - ENSMUSG00000022295
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q5XIY6ENSDARG00000035880Danio rerio
 Q7T385ENSDARG00000023967Danio rerio
 ATP6V1C1ENSGALG00000034099Gallus gallus
 P21283ENSG00000155097Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99L60 / Atp6v1c2 / ATPase, H+ transporting, lysosomal V1 subunit C2 / Q8NEY4* / ATPase H+ transporting V1 subunit C2*ENSMUSG0000002056661


Protein motifs (from Interpro)
Interpro ID Name
 IPR004907  ATPase, V1 complex, subunit C
 IPR036132  Vacuolar ATP synthase subunit C superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0015991 ATP hydrolysis coupled proton transport IEA
 cellular_componentGO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005765 lysosomal membrane IBA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0033180 proton-transporting V-type ATPase, V1 domain IEA
 cellular_componentGO:0045177 apical part of cell IEA
 molecular_functionGO:0008553 proton-exporting ATPase activity, phosphorylative mechanism IDA
 molecular_functionGO:0015078 proton transmembrane transporter activity IEA
 molecular_functionGO:0046961 proton-transporting ATPase activity, rotational mechanism IBA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Insulin receptor recycling
Transferrin endocytosis and recycling
Ion channel transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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