ENSMUSG00000022312


Mus musculus

Features
Gene ID: ENSMUSG00000022312
  
Biological name :Eif3h
  
Synonyms : Eif3h / Eukaryotic translation initiation factor 3 subunit H / Q91WK2
  
Possible biological names infered from orthology : O15372
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: C
Gene start: 51786558
Gene end: 51865523
  
Corresponding Affymetrix probe sets: 10428554 (MoGene1.0st)   1415962_at (Mouse Genome 430 2.0 Array)   1434323_at (Mouse Genome 430 2.0 Array)   1434324_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022925
NCBI entrez gene - 68135     See in Manteia.
MGI - MGI:1915385
RefSeq - NM_080635
RefSeq Peptide - NP_542366
swissprot - Q5M9L0
swissprot - Q91WK2
Ensembl - ENSMUSG00000022312
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO704771.1ENSDARG00000116963Danio rerio
 EIF3HENSGALG00000040522Gallus gallus
 EIF3HENSG00000147677Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000555  JAB1/MPN/MOV34 metalloenzyme domain
 IPR027524  Eukaryotic translation initiation factor 3 subunit H
 IPR037518  MPN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001732 formation of cytoplasmic translation initiation complex IEA
 biological_processGO:0002183 cytoplasmic translational initiation IEA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005852 eukaryotic translation initiation factor 3 complex IDA
 cellular_componentGO:0016282 eukaryotic 43S preinitiation complex IEA
 cellular_componentGO:0033290 eukaryotic 48S preinitiation complex IEA
 cellular_componentGO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m IDA
 molecular_functionGO:0003743 translation initiation factor activity ISO
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dbn1tm1a(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1a(KOMP)Wtsi/Wtsi

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dbn1tm1a(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1a(KOMP)Wtsi/Wtsi

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Dbn1tm1a(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1a(KOMP)Wtsi/Wtsi

 MP:0009687 empty decidua capsularis "the implanted embryo normally covered opposite the placenta by uterine mucosa and epithelium following implantation is missing, suggesting the embryo died early during implantation but after the decidual response and modification of uterine stromal cells" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg
Genetic Background: involves: 129S1/Sv

Allelic Composition: Eif3hMommeD38/Eif3hMommeD38,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg
Genetic Background: involves: 129S1/Sv

Allelic Composition: Eif3hMommeD38/Eif3hMommeD38,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Eif3hMommeD38/Eif3hMommeD38,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: C57BL/6J * FVB/NJ

Allelic Composition: Eif3htm1a(EUCOMM)Hmgu/Eif3htm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Eif3htm1a(EUCOMM)Hmgu/Wtsi

 MP:0012167 abnormal epigenetic regulation of gene expression "any anomaly in the process that modulates the frequency, rate or extent of gene expression, in which the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence" [GO:0040029]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg
Genetic Background: involves: 129S1/Sv

Allelic Composition: Eif3hMommeD38/Eif3h+,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: C57BL/6J * FVB/NJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr