ENSMUSG00000022322


Mus musculus

Features
Gene ID: ENSMUSG00000022322
  
Biological name :Shcbp1
  
Synonyms : Q9Z179 / Shcbp1 / SHC SH2 domain-binding protein 1
  
Possible biological names infered from orthology : Q8NEM2 / SHC binding and spindle associated 1
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A1.1
Gene start: 4735976
Gene end: 4779567
  
Corresponding Affymetrix probe sets: 10576883 (MoGene1.0st)   1416299_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022945
Ensembl peptide - ENSMUSP00000146454
Ensembl peptide - ENSMUSP00000146339
NCBI entrez gene - 20419     See in Manteia.
MGI - MGI:1338802
RefSeq - NM_011369
RefSeq Peptide - NP_035499
swissprot - A0A140LHK7
swissprot - A0A140LHA7
swissprot - Q9Z179
Ensembl - ENSMUSG00000022322
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 shcbp1ENSDARG00000102068Danio rerio
 SHCBP1ENSGALG00000004444Gallus gallus
 Q8NEM2ENSG00000171241Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3TTP0 / Shcbp1l / Testicular spindle-associated protein SHCBP1L / Q9BZQ2* / SHC binding and spindle associated 1 like*ENSMUSG0000004270826


Protein motifs (from Interpro)
Interpro ID Name
 IPR006626  Parallel beta-helix repeat
 IPR011050  Pectin lyase fold/virulence factor
 IPR012334  Pectin lyase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IMP
 biological_processGO:2000177 regulation of neural precursor cell proliferation IMP
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030496 midbody IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042169 SH2 domain binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ryr2tm2Amks/Ryr2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Cd22tm2Tft/Cd22tm2Tft
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd22tm2Tft/Cd22tm2Tft
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Shcbp1tm1c(EUCOMM)Wtsi/Shcbp1tm1c(EUCOMM)Wtsi,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd22tm2Tft/Cd22tm2Tft
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd22tm2Tft/Cd22tm2Tft
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd22tm2Tft/Cd22tm2Tft
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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