ENSMUSG00000042708


Mus musculus

Features
Gene ID: ENSMUSG00000042708
  
Biological name :Shcbp1l
  
Synonyms : Q3TTP0 / Shcbp1l / Testicular spindle-associated protein SHCBP1L
  
Possible biological names infered from orthology : Q9BZQ2 / SHC binding and spindle associated 1 like
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: G3
Gene start: 153425162
Gene end: 153452574
  
Corresponding Affymetrix probe sets: 10350710 (MoGene1.0st)   1429324_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036347
Ensembl peptide - ENSMUSP00000137625
NCBI entrez gene - 71836     See in Manteia.
MGI - MGI:1919086
RefSeq - NM_001033162
RefSeq - XM_006529876
RefSeq Peptide - NP_001028334
swissprot - J3QQ47
swissprot - Q3TTP0
Ensembl - ENSMUSG00000042708
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9BZQ2ENSG00000157060Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Z179 / Shcbp1 / SHC SH2 domain-binding protein 1 / Q8NEM2* / SHC binding and spindle associated 1*ENSMUSG0000002232227


Protein motifs (from Interpro)
Interpro ID Name
 IPR006626  Parallel beta-helix repeat
 IPR006633  Carbohydrate-binding/sugar hydrolysis domain
 IPR011050  Pectin lyase fold/virulence factor
 IPR012334  Pectin lyase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:2001252 positive regulation of chromosome organization IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0072687 meiotic spindle IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0009761 abnormal meiotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during meiosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
Show

Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0014052 increased male germ cell apoptosis "greater number of male germs cells that undergo programmed cell death" [MGI:csmith]
Show

Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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