ENSMUSG00000022330


Mus musculus

Features
Gene ID: ENSMUSG00000022330
  
Biological name :Osr2
  
Synonyms : Osr2 / Protein odd-skipped-related 2 / Q91ZD1
  
Possible biological names infered from orthology : odd-skipped related transciption factor 2 / Q8N2R0
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: B3.1
Gene start: 35296098
Gene end: 35303305
  
Corresponding Affymetrix probe sets: 10423654 (MoGene1.0st)   1426155_a_at (Mouse Genome 430 2.0 Array)   1430950_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022952
Ensembl peptide - ENSMUSP00000154286
NCBI entrez gene - 107587     See in Manteia.
MGI - MGI:1930813
RefSeq - XM_006520013
RefSeq - NM_054049
RefSeq Peptide - NP_473390
swissprot - Q91ZD1
Ensembl - ENSMUSG00000022330
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 osr2ENSDARG00000038006Danio rerio
 OSR2ENSGALG00000037695Gallus gallus
 OSR2ENSG00000164920Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Osr1 / Q9WVG7 / Protein odd-skipped-related 1 / Q8TAX0* / odd-skipped related transciption factor 1*ENSMUSG0000004838763


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0001656 metanephros development IEP
 biological_processGO:0001823 mesonephros development IEP
 biological_processGO:0002062 chondrocyte differentiation IGI
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0009792 embryo development ending in birth or egg hatching IEP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0030154 cell differentiation IGI
 biological_processGO:0030501 positive regulation of bone mineralization IGI
 biological_processGO:0033687 osteoblast proliferation IMP
 biological_processGO:0035115 embryonic forelimb morphogenesis IGI
 biological_processGO:0035116 embryonic hindlimb morphogenesis IEP
 biological_processGO:0036023 embryonic skeletal limb joint morphogenesis IGI
 biological_processGO:0042474 middle ear morphogenesis IMP
 biological_processGO:0042476 odontogenesis IMP
 biological_processGO:0042733 embryonic digit morphogenesis IGI
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048704 embryonic skeletal system morphogenesis IMP
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IMP
 biological_processGO:0060021 roof of mouth development IMP
 biological_processGO:0060272 embryonic skeletal joint morphogenesis IMP
 biological_processGO:0060322 head development IMP
 biological_processGO:0060349 bone morphogenesis IMP
 biological_processGO:0061029 eyelid development in camera-type eye IMP
 biological_processGO:0072498 embryonic skeletal joint development IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000030 abnormal tympanic ring morphology "malformed bony ring at the ear canal to which the tympanic membrane is attached" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
Show

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

Allelic Composition: Osr2tm1Jian/Osr2tm3(Osr1)Jian
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

Allelic Composition: Osr2tm2(cre)Jian/Osr2+,Tg(CAG-Nog)1Ych/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1tm1Mmt,Osr2tm5(cre)Jian/Osr2+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Osr2tm2(cre)Jian/Osr2+,Tg(CAG-Bmp4,-EGFP)1Ypc/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CD-1

 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1tm1Mmt,Osr2tm5(cre)Jian/Osr2+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Osr2tm1Jian/Osr2tm1Jian
Genetic Background: involves: 129S1/Sv

Allelic Composition: Osr2tm1Jian/Osr2tm1Jian,Pax9tm1.1(Osr2)Jian/Pax9+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0000128 growth retardation of molars "developmental delay of the growth of the molars" [J:17489]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Osr2tm2(cre)Jian/Osr2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Osr2tm2(cre)Jian/Osr2+,Tg(CAG-Nog)1Ych/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0000460 mandible hypoplasia "arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
Show

Allelic Composition: Hand2tm1Cse/Hand2tm1Cse,Osr2tm2(cre)Jian/Osr2+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
Show

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

Allelic Composition: Osr2tm3(Osr1)Jian/Osr2tm3(Osr1)Jian
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
Show

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

Allelic Composition: Osr2tm3(Osr1)Jian/Osr2tm3(Osr1)Jian
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Osr2tm1Jian/Osr2tm3(Osr1)Jian
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Osr2tm4(Osr2*)Jian/Osr2tm4(Osr2*)Jian
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Osr2tm1Jian/Osr2tm4(Osr2*)Jian
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1tm1Mmt,Osr2tm5(cre)Jian/Osr2+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Osr2tm2(cre)Jian/Osr2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf14tm1Dor/Fgf14tm1Dor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Osr2tm1Pzg/Osr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Csf1op/Csf1op,Galctwi/Galctwi
Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Csf1op/Csf1op,Galctwi/Galctwi
Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Osr2tm2(cre)Jian/Osr2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003190 fused synovial joints "partial or complete absence of separations containing synovial fluid between bones" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93028]
Show

Allelic Composition: Csf1op/Csf1op,Galctwi/Galctwi
Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J

Allelic Composition: Osr2tm1Jian/Osr2tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0004033 supernumerary teeth "occurrence of more than the usual number of teeth" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

Allelic Composition: Osr2tm1Jian/Osr2tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0005359 growth retardation of incisors "developmental delay of the growth of the incisors, the long pointed teeth, most anterior and prominent in the jaw " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Osr2tm2(cre)Jian/Osr2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006020 reduced size of tympanic ring "smaller than average tympanic ring" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0009263 abnormal eyelid fusion "anomaly in the process by which the upper and lower eyelids are joined during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Osr2tm3(Osr1)Jian/Osr2tm3(Osr1)Jian
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0009264 failure of eyelid fusion "the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye do not fuse together during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

Allelic Composition: Osr1tm2Jian/Osr1tm2Jian,Osr2tm1Jian/Osr2tm1Jian,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL/J

 MP:0009884 palatal shelf fusion with tongue or mandible "palatal shelves do not elevate during development and instead fuse with tongue tissues or with the mandible tissues" [PMID:16680722]
Show

Allelic Composition: Osr2tm2(cre)Jian/Osr2+,Tg(CAG-Bmp4,-EGFP)1Ypc/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CD-1

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
Show

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

Allelic Composition: Osr2tm2(cre)Jian/Osr2+,Tg(CAG-Bmp4,-EGFP)1Ypc/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CD-1

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
Show

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Osr2tm2(cre)Jian/Osr2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Osr2tm1Jian/Osr2tm1Jian
Genetic Background: involves: 129S1/Sv

Allelic Composition: Osr2tm1Jian/Osr2tm1Jian,Pax9tm1.2(Osr2)Jian/Pax9+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6J * FVB/N

Allelic Composition: Osr2tm1Jian/Osr2tm1Jian,Pax9tm1.1(Osr2)Jian/Pax9+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0010864 abnormal enamel knot morphology "any structural anomaly of a transient cluster of cells in the central part of the dental epithelium facing the dental mesenchyme, which acts as an organizing center, providing positional information for tooth morphogenesis and regulating the growth of tooth cusps" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8808404]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Osr2tm2(cre)Jian/Osr2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Enpp2tm1.1Vart/Enpp2tm1.1Vart,Sox1tm2Vep/Sox1+
Genetic Background: involves: C57BL/6

 MP:0012163 abnormal dental mesenchyme morphology "any structural anomaly of the mesenchyme enclosed by dental organ" [MGI:anna]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1tm1Mmt,Osr2tm5(cre)Jian/Osr2+
Genetic Background: involves: 129X1/SvJ

 MP:0030136 abnormal lower incisor morphology "any structural anomaly of the lower set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
Show

Allelic Composition: Pax9tm1.1(Osr2)Jian/Pax9tm1.1(Osr2)Jian
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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