ENSMUSG00000048387


Mus musculus

Features
Gene ID: ENSMUSG00000048387
  
Biological name :Osr1
  
Synonyms : Osr1 / Protein odd-skipped-related 1 / Q9WVG7
  
Possible biological names infered from orthology : odd-skipped related transciption factor 1 / Q8TAX0
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A1.1
Gene start: 9570116
Gene end: 9581500
  
Corresponding Affymetrix probe sets: 10394534 (MoGene1.0st)   1449350_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151780
Ensembl peptide - ENSMUSP00000055486
NCBI entrez gene - 23967     See in Manteia.
MGI - MGI:1344424
RefSeq - NM_011859
RefSeq Peptide - NP_035989
swissprot - A0A1W2P7S2
swissprot - Q9WVG7
Ensembl - ENSMUSG00000048387
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 osr1ENSDARG00000014091Danio rerio
 OSR1ENSGALG00000016473Gallus gallus
 OSR1ENSG00000143867Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Osr2 / Q91ZD1 / Protein odd-skipped-related 2 / Q8N2R0* / odd-skipped related transciption factor 2*ENSMUSG0000002233066


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0001655 urogenital system development IMP
 biological_processGO:0001656 metanephros development IMP
 biological_processGO:0001657 ureteric bud development IMP
 biological_processGO:0001823 mesonephros development IMP
 biological_processGO:0002062 chondrocyte differentiation IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007231 osmosensory signaling pathway IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008406 gonad development IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0023016 signal transduction by trans-phosphorylation IEA
 biological_processGO:0030154 cell differentiation IGI
 biological_processGO:0030501 positive regulation of bone mineralization IGI
 biological_processGO:0030857 negative regulation of epithelial cell differentiation IMP
 biological_processGO:0035115 embryonic forelimb morphogenesis IGI
 biological_processGO:0035116 embryonic hindlimb morphogenesis IGI
 biological_processGO:0036023 embryonic skeletal limb joint morphogenesis IGI
 biological_processGO:0042474 middle ear morphogenesis IGI
 biological_processGO:0042476 odontogenesis IGI
 biological_processGO:0042733 embryonic digit morphogenesis IGI
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048389 intermediate mesoderm development IMP
 biological_processGO:0048793 pronephros development IEA
 biological_processGO:0048863 stem cell differentiation IDA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IGI
 biological_processGO:0060021 roof of mouth development IGI
 biological_processGO:0060272 embryonic skeletal joint morphogenesis IGI
 biological_processGO:0071300 cellular response to retinoic acid IEP
 biological_processGO:0072075 metanephric mesenchyme development IDA
 biological_processGO:0072111 cell proliferation involved in kidney development IMP
 biological_processGO:0072133 metanephric mesenchyme morphogenesis IMP
 biological_processGO:0072143 mesangial cell development IMP
 biological_processGO:0072162 metanephric mesenchymal cell differentiation IMP
 biological_processGO:0072166 posterior mesonephric tubule development IMP
 biological_processGO:0072168 specification of anterior mesonephric tubule identity IMP
 biological_processGO:0072169 specification of posterior mesonephric tubule identity IMP
 biological_processGO:0072180 mesonephric duct morphogenesis IMP
 biological_processGO:0072183 negative regulation of nephron tubule epithelial cell differentiation IMP
 biological_processGO:0072184 renal vesicle progenitor cell differentiation IMP
 biological_processGO:0072190 ureter urothelium development IMP
 biological_processGO:0072207 metanephric epithelium development IMP
 biological_processGO:0072208 metanephric smooth muscle tissue development IMP
 biological_processGO:0072234 metanephric nephron tubule development IMP
 biological_processGO:0072239 metanephric glomerulus vasculature development IMP
 biological_processGO:0072259 metanephric interstitial fibroblast development IMP
 biological_processGO:0072268 pattern specification involved in metanephros development IMP
 biological_processGO:0072498 embryonic skeletal joint development IGI
 biological_processGO:0090094 metanephric cap mesenchymal cell proliferation involved in metanephros development IMP
 biological_processGO:1905408 negative regulation of creatine transmembrane transporter activity IEA
 biological_processGO:2000543 positive regulation of gastrulation IEA
 biological_processGO:2000650 negative regulation of sodium ion transmembrane transporter activity IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0019898 extrinsic component of membrane IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0000282 abnormal atrial septum morphology "abnormality in the wall between the atria of the heart, usually incomplete closure " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0000288 abnormal pericardium morphology "malformation of the fibroserous membrane covering the heart and beginning of the great vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:54408]
Show

Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
Show

Allelic Composition: Pax3Sp-2J/Pax3Sp-2J
Genetic Background: either: C3H/HeJ-Pax3Sp-2J or (involves: C3H/HeJ * C57BL/6J)

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
Show

Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Osr1tm2.2Jian/Osr1tm2.2Jian
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Osr1tm2.2Jian/Osr1tm2.2Jian
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Osr1tm2.2Jian/Osr1tm2.2Jian
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Csf1op/Csf1op,Galctwi/Galctwi
Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Csf1op/Csf1op,Galctwi/Galctwi
Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: ApcMin/Apc+,Glp2rtm1Ddr/Glp2r+
Genetic Background: involves: C57BL/6J

Allelic Composition: Osr1tm2.2Jian/Osr1tm2.2Jian
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0002725 abnormal vein morphology "malformation of the blood vessels that carry blood towards the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Csf1op/Csf1op,Galctwi/Galctwi
Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Csf1op/Csf1op,Galctwi/Galctwi
Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J

 MP:0003057 abnormal epicardium morphology "anomalous structure of the visceral layer of the pericardium that surrounds and attaches to all the surfaces of the heart" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Osr1tm2.2Jian/Osr1tm2.2Jian
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0003190 fused synovial joints "partial or complete absence of separations containing synovial fluid between bones" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93028]
Show

Allelic Composition: Csf1op/Csf1op,Galctwi/Galctwi
Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J

 MP:0003578 absent ovary "absence of the female reproductive gland containing the germ cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0003827 abnormal Wolffian duct morphology "malformation of the transient embryonic tubes that empty into the cloca and degenerate in the male " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0005313 absent adrenal gland "missing endocrine glands that are normally located above the kidney and responsible for hormone and epinepherine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56651]
Show

Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0005644 agonadal "denoting the absence of gonads" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0006107 abnormal atrioventricular canal morphology "malformation or anomaly in development of the common canal connecting the primordial atrium and ventricle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93610]
Show

Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0006415 absent testes "absence of the male reproductive glands containing the germ cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0008487 abnormal mesonephros morphology "any structural anomaly of the excretory organ of the embryo, collective Wolffian tubules, which forms the urogenital fold from which the reproductive organs develop" [MESH:A16.254.500]
Show

Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0009075 rudimentary Wolffian ducts "not fully developed or remnants of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and later develop into the ductus deferens in the male" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0009264 failure of eyelid fusion "the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye do not fuse together during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csf1op/Csf1op,Galctwi/Galctwi
Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J

 MP:0010406 absent atrial septum "absence of the thin membranous structure between the two heart atria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csf1op/Csf1op,Galctwi/Galctwi
Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J

 MP:0010978 absent ureteric bud "absence of the epithelial swelling on the Wolffian duct that elongates to invade the adjacent metanephric mesenchyme" [PMID:19828308]
Show

Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0010984 abnormal metanephric mesenchyme morphology "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing metanephros; interactions between the ureteric bud and the metanephric mesenchyme leads to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:19828308]
Show

Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0010986 abnormal mesonephric mesenchyme morphology "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing mesonephros" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0010987 abnormal nephrogenic mesenchyme morphogenesis "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing nephron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Pax3Sp-2J/Pax3Sp-2J
Genetic Background: either: C3H/HeJ-Pax3Sp-2J or (involves: C3H/HeJ * C57BL/6J)

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Osr1tm2.2Jian/Osr1tm2.2Jian
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Pax3Sp-2J/Pax3Sp-2J
Genetic Background: either: C3H/HeJ-Pax3Sp-2J or (involves: C3H/HeJ * C57BL/6J)

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0011366 absent metanephros "absence of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord" [MGI:anna]
Show

Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0011386 increased metanephric mesenchyme apoptosis "increase in the number of cells of the metanephric mesenchyme (MM) undergoing programmed cell death; usually due to failure of MM cells to interact with the ureteric bud (UB) tips after UB invasion" [MGI:anna]
Show

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0011387 absent metanephric mesenchyme "absence of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing metanephros; normally, interactions between the ureteric bud and the metanephric mesenchyme lead to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue" [MGI:anna]
Show

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0011412 gonadal ridge hypoplasia "underdevelopment or reduced size of the elevation of thickened mesothelium and underlying mesenchyme found on the ventromedial border of the embryonic mesonephros, usually due to reduced cell number; normally, primordial germ cells become embedded in it, establishing it as the primordium of the testis or ovary" [MGI:anna]
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Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0013164 abnormal forelimb bud morphology "any structural anomaly of the limb bud that develops into a forelimb (usually the arm or front limb in mammalian species)" [MGI:anna]
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Allelic Composition: Osr1tm2.2Jian/Osr1tm2.2Jian
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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