ENSMUSG00000022335


Mus musculus

Features
Gene ID: ENSMUSG00000022335
  
Biological name :Zfat
  
Synonyms : Q7TS63 / Zfat / zinc finger and AT hook domain containing
  
Possible biological names infered from orthology : Q9P243
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D2
Gene start: 68083764
Gene end: 68258856
  
Corresponding Affymetrix probe sets: 10429178 (MoGene1.0st)   1441676_at (Mouse Genome 430 2.0 Array)   1443774_at (Mouse Genome 430 2.0 Array)   1443775_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124974
Ensembl peptide - ENSMUSP00000125257
Ensembl peptide - ENSMUSP00000125732
NCBI entrez gene - 380993     See in Manteia.
MGI - MGI:2681865
RefSeq - XM_011245683
RefSeq - NM_001145888
RefSeq - NM_198644
RefSeq - XM_006521124
RefSeq - XM_006521125
RefSeq - XM_006521127
RefSeq Peptide - NP_001139360
RefSeq Peptide - NP_941046
swissprot - E0CX30
swissprot - Q7TS63
Ensembl - ENSMUSG00000022335
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zfatENSDARG00000077987Danio rerio
 ZFATENSGALG00000037698Gallus gallus
 ZFATENSG00000066827Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zfp408 / zinc finger protein 408 / Q9H9D4* / ZNF408*ENSMUSG0000007504012


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060712 spongiotrophoblast layer development IMP
 cellular_componentGO:0005634 nucleus IC
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Dok3tm1Brs/Dok3tm1Brs
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0003396 abnormal embryonic hematopoiesis "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans " [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Dok3tm1Brs/Dok3tm1Brs
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Dok3tm1Brs/Dok3tm1Brs
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0004255 abnormal spongiotrophoblast layer morphology "anomaly in the structure of the outer structural layer of the rodent placenta" [PMID:11433360]
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Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Dok3tm1Brs/Dok3tm1Brs
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Defb41tm1(icre)Psip/Defb41+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Defb41tm1(icre)Psip/Defb41+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Defb41tm1(icre)Psip/Defb41+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Defb41tm1(icre)Psip/Defb41+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Defb41tm1(icre)Psip/Defb41+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0008080 abnormal CD8-positive T cell differentiation "atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Defb41tm1(icre)Psip/Defb41+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Defb41tm1(icre)Psip/Defb41+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Dok3tm1Brs/Dok3tm1Brs
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0011204 abnormal visceral yolk sac blood island morphology "any structural anomaly of the masses of developing blood cells attached to endothelium in the yolk sac" [PMID:16140152]
Show

Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Dok3tm1Brs/Dok3tm1Brs
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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