ENSMUSG00000022429


Mus musculus

Features
Gene ID: ENSMUSG00000022429
  
Biological name :Dmc1
  
Synonyms : Dmc1 / Meiotic recombination / Q61880
  
Possible biological names infered from orthology : DNA meiotic recombinase 1 / Q14565
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E1
Gene start: 79561497
Gene end: 79605109
  
Corresponding Affymetrix probe sets: 10430555 (MoGene1.0st)   1420335_at (Mouse Genome 430 2.0 Array)   1449819_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023065
Ensembl peptide - ENSMUSP00000154933
Ensembl peptide - ENSMUSP00000155228
NCBI entrez gene - 13404     See in Manteia.
MGI - MGI:105393
RefSeq - XM_006520409
RefSeq - NM_001278226
RefSeq - NM_010059
RefSeq - XM_006520407
RefSeq - XM_006520408
RefSeq Peptide - NP_001265155
RefSeq Peptide - NP_034189
swissprot - Q61880
swissprot - Q8C610
swissprot - Q14AN8
Ensembl - ENSMUSG00000022429
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dmc1ENSDARG00000055883Danio rerio
 DMC1ENSGALG00000012236Gallus gallus
 DMC1ENSG00000100206Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR010995  DNA repair Rad51/transcription factor NusA, alpha-helical
 IPR011940  Meiotic recombinase Dmc1
 IPR013632  DNA recombination and repair protein Rad51-like, C-terminal
 IPR016467  DNA recombination and repair protein, RecA-like
 IPR020587  DNA recombination and repair protein RecA, monomer-monomer interface
 IPR020588  DNA recombination and repair protein RecA-like, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR033925  Rad51/DMC1/RadA


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000730 DNA recombinase assembly IBA
 biological_processGO:0001541 ovarian follicle development IMP
 biological_processGO:0001556 oocyte maturation IMP
 biological_processGO:0006259 DNA metabolic process IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006312 mitotic recombination IBA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007129 synapsis IMP
 biological_processGO:0007131 reciprocal meiotic recombination IBA
 biological_processGO:0007141 male meiosis I IMP
 biological_processGO:0007276 gamete generation IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0010212 response to ionizing radiation IBA
 biological_processGO:0042148 strand invasion IBA
 biological_processGO:0051321 meiotic cell cycle IEA
 cellular_componentGO:0000781 chromosome, telomeric region IDA
 cellular_componentGO:0000794 condensed nuclear chromosome IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0000150 recombinase activity ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000400 four-way junction DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding ISS
 molecular_functionGO:0003697 single-stranded DNA binding IBA
 molecular_functionGO:0004520 endodeoxyribonuclease activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008094 DNA-dependent ATPase activity IEA
 molecular_functionGO:0016887 ATPase activity ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Tgfb3tm2(Tgfb1)Vk/Tgfb3tm2(Tgfb1)Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dmc1Mei11/Dmc1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Dmc1tm1Jcs/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Dmc1Mei11/Dmc1+
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dmc1Mei11/Dmc1+
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

Allelic Composition: Dmc1Mei11/Dmc1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Dmc1tm1Jcs/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001931 abnormal oogenesis "atypical formation or failure to form the female germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fbn2fp-3J/Fbn2fp-3J
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fbn2fp-3J/Fbn2fp-3J
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dmc1tm1Jcs/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004805 absent oocytes "absence of mature germ cells in the female" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dmc1tm1Jcs/Dmc1tm1Jcs,Hormad2tm1.2Atot/Hormad2tm1.2Atot
Genetic Background: involves: 129 * BALB/c * C57BL/6 * SJL

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0004856 decreased ovary weight "reduction in the average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Dmc1Mei11/Dmc1+
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

Allelic Composition: Dmc1Mei11/Dmc1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Spo11tm2.1Rdco/Spo11tm2.1Rdco
Genetic Background: B6.129S6-Spo11tm2.1Rdco

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dmc1Mei11/Dmc1+
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

Allelic Composition: Dmc1tm1Jcs/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmc1Mei11/Dmc1+
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

Allelic Composition: Dmc1tm1Jcs/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dmc1Mei11/Dmc1+
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

Allelic Composition: Dmc1Mei11/Dmc1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Dmc1tm1Jcs/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
Show

Allelic Composition: Hormad1tm1Atot/Hormad1tm1Atot,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd

Allelic Composition: Dmc1tm1Jcs/Dmc1tm1Jcs,Hormad1tm1.2Atot/Hormad1tm1.2Atot
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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