ENSMUSG00000022453


Mus musculus

Features
Gene ID: ENSMUSG00000022453
  
Biological name :Naga
  
Synonyms : Alpha-N-acetylgalactosaminidase / Naga / Q9QWR8
  
Possible biological names infered from orthology : P17050
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E1
Gene start: 82329532
Gene end: 82338925
  
Corresponding Affymetrix probe sets: 10430834 (MoGene1.0st)   1449043_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000155808
Ensembl peptide - ENSMUSP00000023088
Ensembl peptide - ENSMUSP00000154927
Ensembl peptide - ENSMUSP00000155062
Ensembl peptide - ENSMUSP00000155110
Ensembl peptide - ENSMUSP00000155159
Ensembl peptide - ENSMUSP00000155238
Ensembl peptide - ENSMUSP00000155445
NCBI entrez gene - 17939     See in Manteia.
MGI - MGI:1261422
RefSeq - NM_008669
RefSeq - XM_006520563
RefSeq - XM_006520561
RefSeq - XM_006520562
RefSeq Peptide - NP_032695
swissprot - Q3UZX5
swissprot - Q9QWR8
Ensembl - ENSMUSG00000022453
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nagaENSDARG00000099313Danio rerio
 NAGAENSGALG00000011900Gallus gallus
 NAGAENSG00000198951Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gla / galactosidase, alpha / P06280*ENSMUSG0000003126647


Protein motifs (from Interpro)
Interpro ID Name
 IPR000111  Glycoside hydrolase family 27/36, conserved site
 IPR002241  Glycoside hydrolase, family 27
 IPR013785  Aldolase-type TIM barrel
 IPR017853  Glycoside hydrolase superfamily
 IPR035373  Alpha galactosidase A, C-terminal beta-sandwich domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009311 oligosaccharide metabolic process IBA
 biological_processGO:0016052 carbohydrate catabolic process IEA
 biological_processGO:0016139 glycoside catabolic process IBA
 biological_processGO:0019377 glycolipid catabolic process IEA
 biological_processGO:0046477 glycosylceramide catabolic process IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005764 lysosome IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds IEA
 molecular_functionGO:0004557 alpha-galactosidase activity IBA
 molecular_functionGO:0008456 alpha-N-acetylgalactosaminidase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010850 increased effector memory CD8-positive, alpha-beta T cell number "increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]
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Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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