ENSMUSG00000031266


Mus musculus

Features
Gene ID: ENSMUSG00000031266
  
Biological name :Gla
  
Synonyms : galactosidase, alpha / Gla
  
Possible biological names infered from orthology : P06280
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: E3
Gene start: 134588149
Gene end: 134601125
  
Corresponding Affymetrix probe sets: 10606714 (MoGene1.0st)   1418248_at (Mouse Genome 430 2.0 Array)   1449006_at (Mouse Genome 430 2.0 Array)   1459738_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123098
Ensembl peptide - ENSMUSP00000033621
NCBI entrez gene - 11605     See in Manteia.
MGI - MGI:1347344
RefSeq - NM_013463
RefSeq Peptide - NP_038491
swissprot - A2BDV6
swissprot - Q8BGZ6
Ensembl - ENSMUSG00000031266
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 glaENSDARG00000036155Danio rerio
 GLAENSGALG00000004948Gallus gallus
 GLAENSG00000102393Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Naga / Q9QWR8 / Alpha-N-acetylgalactosaminidase / P17050*ENSMUSG0000002245347


Protein motifs (from Interpro)
Interpro ID Name
 IPR000111  Glycoside hydrolase family 27/36, conserved site
 IPR002241  Glycoside hydrolase, family 27
 IPR013785  Aldolase-type TIM barrel
 IPR017853  Glycoside hydrolase superfamily
 IPR035373  Alpha galactosidase A, C-terminal beta-sandwich domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009311 oligosaccharide metabolic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds IEA
 molecular_functionGO:0004557 alpha-galactosidase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0016936 galactoside binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Glycosphingolipid metabolism
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Crabp1tm1Ipc/Crabp1tm1Ipc
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Crabp1tm1Ipc/Crabp1tm1Ipc
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Acta1tm1Jll/Acta1+,Tg(ACTA1*D286G)#Kjno/Tg(ACTA1*D286G)#Kjno
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Glatm1Kul/Y,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Acta1tm1Jll/Acta1+,Tg(ACTA1*D286G)#Kjno/Tg(ACTA1*D286G)#Kjno
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Glatm1Kul/Y,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Glatm1Kul/Glatm1Kul,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

Allelic Composition: Glatm1Kul/Y,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acta1tm1Jll/Acta1+,Tg(ACTA1*D286G)#Kjno/Tg(ACTA1*D286G)#Kjno
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Glatm1Kul/Y,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: B6.129S2-Drd2tm1Ebo

Allelic Composition: Glatm1Kul/Y,Itpr1wblo/Itpr1wblo
Genetic Background: B6;129-Glatm1Kul Itpr1wblo/GrsrJ

Allelic Composition: Glatm1Kul/Glatm1Kul,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

Allelic Composition: Glatm1Kul/Y,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
Show

Allelic Composition: Glatm1Kul/Glatm1Kul,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

Allelic Composition: Glatm1Kul/Y,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acta1tm1Jll/Acta1+,Tg(ACTA1*D286G)#Kjno/Tg(ACTA1*D286G)#Kjno
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Glatm1Kul/Y,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Crabp1tm1Ipc/Crabp1tm1Ipc
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
Show

Allelic Composition: Crabp1tm1Ipc/Crabp1tm1Ipc
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Glatm1Kul/Glatm1Kul,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

Allelic Composition: Glatm1Kul/Y,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acta1tm1Jll/Acta1+,Tg(ACTA1*D286G)#Kjno/Tg(ACTA1*D286G)#Kjno
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Glatm1Kul/Y,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Crabp1tm1Ipc/Crabp1tm1Ipc
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Crabp1tm1Ipc/Crabp1tm1Ipc
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Glatm1Kul/Glatm1Kul,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

Allelic Composition: Glatm1Kul/Y,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Crabp1tm1Ipc/Crabp1tm1Ipc
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Glatm1Kul/Glatm1Kul,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

Allelic Composition: Glatm1Kul/Y,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Glatm1Kul/Y,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
Show

Allelic Composition: Glatm1Kul/Glatm1Kul,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

Allelic Composition: Glatm1Kul/Y,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Glatm1Kul/Glatm1Kul,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

Allelic Composition: Glatm1Kul/Y,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

 MP:0005326 abnormal podocytes "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971]
Show

Allelic Composition: Glatm1Kul/Y,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
Show

Allelic Composition: Crabp1tm1Ipc/Crabp1tm1Ipc
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Crabp1tm1Ipc/Crabp1tm1Ipc
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Glatm1Kul/Glatm1Kul,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

Allelic Composition: Glatm1Kul/Y,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
Show

Allelic Composition: Crabp1tm1Ipc/Crabp1tm1Ipc
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010506 prolonged RR interval "increase in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crabp1tm1Ipc/Crabp1tm1Ipc
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010574 aorta dilation "the luminal space of the aorta is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crabp1tm1Ipc/Crabp1tm1Ipc
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011556 increased urine beta2-microglobulin level "greater than the normal amount of beta2-microglobulin in the urine; may indicate renal tubule disease, drug-induced renal toxicity, heavy metal-induced renal disease, lymphomas, leukemia, or myeloma" [MGI:anna]
Show

Allelic Composition: Glatm1Kul/Glatm1Kul,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

Allelic Composition: Glatm1Kul/Y,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Glatm1Kul/Y,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031266 Gla / galactosidase, alpha / P06280*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr