ENSMUSG00000022494


Mus musculus

Features
Gene ID: ENSMUSG00000022494
  
Biological name :Shisa9
  
Synonyms : Protein shisa-9 / Q9CZN4 / Shisa9
  
Possible biological names infered from orthology : B4DS77 / shisa family member 9
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A1
Gene start: 11984113
Gene end: 12270902
  
Corresponding Affymetrix probe sets: 10433618 (MoGene1.0st)   1435424_x_at (Mouse Genome 430 2.0 Array)   1453428_at (Mouse Genome 430 2.0 Array)   1456995_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023138
Ensembl peptide - ENSMUSP00000132646
NCBI entrez gene - 72555     See in Manteia.
MGI - MGI:1919805
RefSeq - NM_001174086
RefSeq - NM_028277
RefSeq Peptide - NP_001167557
RefSeq Peptide - NP_082553
swissprot - Q9CZN4
swissprot - E9QN38
Ensembl - ENSMUSG00000022494
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 shisa9aENSDARG00000045145Danio rerio
 shisa9bENSDARG00000052642Danio rerio
 SHISA9ENSGALG00000035799Gallus gallus
 B4DS77ENSG00000237515Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3UH99 / Shisa6 / shisa family member 6 / Q6ZSJ9*ENSMUSG0000005393030
Shisa8 / shisa family member 8 / B8ZZ34*ENSMUSG0000009688327
Q8C3Q5 / Shisa7 / Protein shisa-7 / A6NL88* / shisa family member 7*ENSMUSG0000005355027


Protein motifs (from Interpro)
Interpro ID Name
 IPR026910  Shisa family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0048172 regulation of short-term neuronal synaptic plasticity IDA
 biological_processGO:0098962 regulation of postsynaptic neurotransmitter receptor activity IC
 biological_processGO:2000311 regulation of AMPA receptor activity IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008328 ionotropic glutamate receptor complex IDA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0032281 AMPA glutamate receptor complex IDA
 cellular_componentGO:0032591 dendritic spine membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IDA
 cellular_componentGO:0098839 postsynaptic density membrane IC
 molecular_functionGO:0030165 PDZ domain binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002917 decreased synaptic depression "decrease in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Nt5c2tm1.1Aafo/Nt5c2+,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Nt5c2tm1.1Aafo/Nt5c2+,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0004859 abnormal synaptic plasticity "anomaly in the ability of a synapse to change its strength as a result of successive activations" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Trmutm1Tomik/Trmutm1Tomik
Genetic Background: involves: C57BL/6 * DBA

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nt5c2tm1.1Aafo/Nt5c2+,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0011003 reduced AMPA-mediated synaptic currents "reduction in the measured amplitude, current density or duration of response to stimulation of AMPA receptors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nt5c2tm1.1Aafo/Nt5c2+,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0011267 abnormal excitatory postsynaptic current amplitude "anomaly in the size (height or maximum displacement) or shape of the evoked excitatory postsynaptic current wave" [MGI:csmith]
Show

Allelic Composition: Nt5c2tm1.1Aafo/Nt5c2+,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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