ENSMUSG00000022496


Mus musculus

Features
Gene ID: ENSMUSG00000022496
  
Biological name :Tnfrsf17
  
Synonyms : O88472 / Tnfrsf17 / Tumor necrosis factor receptor superfamily member 17
  
Possible biological names infered from orthology : Q02223 / TNF receptor superfamily member 17
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A1
Gene start: 11313812
Gene end: 11320074
  
Corresponding Affymetrix probe sets: 10433584 (MoGene1.0st)   1420782_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023140
NCBI entrez gene - 21935     See in Manteia.
MGI - MGI:1343050
RefSeq - XM_006521990
RefSeq - NM_011608
RefSeq - XM_006521989
RefSeq Peptide - NP_035738
swissprot - O88472
Ensembl - ENSMUSG00000022496
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q02223ENSG00000048462Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015337  BCMA, TALL-1 binding
 IPR022320  Tumour necrosis factor receptor 17


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002260 lymphocyte homeostasis IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0007165 signal transduction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
TNFs bind their physiological receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ncantm3Ref/Ncantm3Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002965 hyperalbuminemia "blood albumin concentration above the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0005568 increased circulating total protein level "greater than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0008098 decreased plasma cell number "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ncantm3Ref/Ncantm3Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010506 prolonged RR interval "increase in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022496 O88472 / Tnfrsf17 / Tumor necrosis factor receptor superfamily member 17 / Q02223* / TNF receptor superfamily member 17*  / reaction / complex
 ENSMUSG00000031497 Q9WU72 / Tnfsf13b / tumor necrosis factor (ligand) superfamily, member 13b / Q9Y275* / TNF superfamily member 13b*  / complex / reaction
 ENSMUSG00000010142 Q9ET35 / Tnfrsf13b / tumor necrosis factor receptor superfamily, member 13b / O14836* / TNF receptor superfamily member 13B*  / complex / reaction
 ENSMUSG00000089669 Tnfsf13 / tumor necrosis factor (ligand) superfamily, member 13 / O75888* / TNF superfamily member 13*  / reaction / complex






 

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