ENSMUSG00000022562


Mus musculus

Features
Gene ID: ENSMUSG00000022562
  
Biological name :Oplah
  
Synonyms : 5-oxoprolinase / Oplah / Q8K010
  
Possible biological names infered from orthology : 5-oxoprolinase, ATP-hydrolysing / O14841
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D3
Gene start: 76296601
Gene end: 76328015
  
Corresponding Affymetrix probe sets: 10429859 (MoGene1.0st)   1424359_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127955
Ensembl peptide - ENSMUSP00000148028
Ensembl peptide - ENSMUSP00000131967
Ensembl peptide - ENSMUSP00000129100
Ensembl peptide - ENSMUSP00000023222
NCBI entrez gene - 75475     See in Manteia.
MGI - MGI:1922725
RefSeq - XM_006521507
RefSeq - XM_006521509
RefSeq - XM_006521508
RefSeq - NM_153122
RefSeq Peptide - NP_694762
swissprot - Q8K010
swissprot - E9Q484
swissprot - A0A1B0GSQ4
swissprot - E9PZB8
Ensembl - ENSMUSG00000022562
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 oplahENSDARG00000045123Danio rerio
 OPLAHENSG00000178814Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002821  Hydantoinase A/oxoprolinase
 IPR003692  Hydantoinase B/oxoprolinase
 IPR008040  Hydantoinaseoxoprolinase, N-terminal
 IPR029385  Speriolin, N-terminal
 IPR036388  Winged helix-like DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006749 glutathione metabolic process IBA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017168 5-oxoprolinase (ATP-hydrolyzing) activity ISS


Pathways (from Reactome)
Pathway description
Glutathione synthesis and recycling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Nxntm1b(EUCOMM)Wtsi/Nxntm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nxntm1b(EUCOMM)Wtsi/Wtsi

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nxntm1b(EUCOMM)Wtsi/Nxntm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nxntm1b(EUCOMM)Wtsi/Wtsi

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Nxntm1b(EUCOMM)Wtsi/Nxntm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nxntm1b(EUCOMM)Wtsi/Wtsi

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Nxntm1b(EUCOMM)Wtsi/Nxntm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nxntm1b(EUCOMM)Wtsi/Wtsi

 MP:0010068 decreased red blood cell distribution width "lower than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]
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Allelic Composition: Nxntm1b(EUCOMM)Wtsi/Nxntm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nxntm1b(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022562 Oplah / Q8K010 / 5-oxoprolinase / O14841* / 5-oxoprolinase, ATP-hydrolysing*  / complex






 

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