ENSMUSG00000022652


Mus musculus

Features
Gene ID: ENSMUSG00000022652
  
Biological name :Morc1
  
Synonyms : Morc1 / MORC family CW-type zinc finger protein 1 / Q9WVL5
  
Possible biological names infered from orthology : MORC family CW-type zinc finger 1 / Q86VD1
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B5
Gene start: 48431237
Gene end: 48630905
  
Corresponding Affymetrix probe sets: 10436057 (MoGene1.0st)   1419418_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023330
NCBI entrez gene - 17450     See in Manteia.
MGI - MGI:1316740
RefSeq - NM_010816
RefSeq Peptide - NP_034946
swissprot - Q9WVL5
Ensembl - ENSMUSG00000022652
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MORC1ENSG00000114487Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Morc2a / Q69ZX6 / MORC family CW-type zinc finger protein 2A / MORC2* / Q9Y6X9* / MORC family CW-type zinc finger 2*ENSMUSG0000003454339
Morc2b / Q8C5W4 / microrchidia 2B / MORC2* / Q9Y6X9* / MORC family CW-type zinc finger 2*ENSMUSG0000004860236
Morc3 / F7BJB9 / MORC family CW-type zinc finger protein 3 / Q14149* / MORC family CW-type zinc finger 3*ENSMUSG0000003945622
Morc4 / Q8BMD7 / MORC family CW-type zinc finger protein 4 / Q8TE76* / MORC family CW-type zinc finger 4*ENSMUSG0000003143420


Protein motifs (from Interpro)
Interpro ID Name
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR011124  Zinc finger, CW-type
 IPR036890  Histidine kinase/HSP90-like ATPase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0010529 negative regulation of transposition IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0040029 regulation of gene expression, epigenetic IMP
 biological_processGO:0043046 DNA methylation involved in gamete generation IMP
 biological_processGO:0044026 DNA hypermethylation IMP
 biological_processGO:2000143 negative regulation of DNA-templated transcription, initiation IMP
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Morc1Tg(Tyr)1Az/Morc1Tg(Tyr)1Az
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Morc1Tg(Tyr)1Az/Morc1Tg(Tyr)1Az
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0003360 depression-related behavior 
Show

Allelic Composition: Morc1Tg(Tyr)1Az/Morc1Tg(Tyr)1Az
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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