ENSMUSG00000048602


Mus musculus

Features
Gene ID: ENSMUSG00000048602
  
Biological name :Morc2b
  
Synonyms : microrchidia 2B / Morc2b / Q8C5W4
  
Possible biological names infered from orthology : MORC2 / MORC family CW-type zinc finger 2 / Q9Y6X9
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B1
Gene start: 33135588
Gene end: 33139683
  
Corresponding Affymetrix probe sets: 10449979 (MoGene1.0st)   1439222_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000056879
Ensembl peptide - ENSMUSP00000123354
NCBI entrez gene - 240069     See in Manteia.
MGI - MGI:3045293
RefSeq - XM_011246444
RefSeq - NM_177719
RefSeq - XM_006524258
RefSeq - XM_006524259
RefSeq - XM_006524257
RefSeq Peptide - NP_808387
swissprot - Q8C5W4
Ensembl - ENSMUSG00000048602
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 morc2ENSDARG00000028539Danio rerio
 MORC2ENSG00000133422Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Morc2a / Q69ZX6 / MORC family CW-type zinc finger protein 2A / MORC2* / Q9Y6X9* / MORC family CW-type zinc finger 2*ENSMUSG0000003454374
Morc1 / Q9WVL5 / MORC family CW-type zinc finger protein 1 / Q86VD1* / MORC family CW-type zinc finger 1*ENSMUSG0000002265234
Morc3 / F7BJB9 / MORC family CW-type zinc finger protein 3 / Q14149* / MORC family CW-type zinc finger 3*ENSMUSG0000003945621
Morc4 / Q8BMD7 / MORC family CW-type zinc finger protein 4 / Q8TE76* / MORC family CW-type zinc finger 4*ENSMUSG0000003143419


Protein motifs (from Interpro)
Interpro ID Name
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR011124  Zinc finger, CW-type
 IPR036890  Histidine kinase/HSP90-like ATPase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008150 biological_process ND
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Fatty acyl-CoA biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0001930 abnormal meiosis "malfunction in the process of nuclear division that results in gametes with one half the normal number of the original cell" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0004805 absent oocytes "absence of mature germ cells in the female" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0009451 abnormal chromosome pairing during meiosis "an anomaly in the highly specific side-by-side association of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0014052 increased male germ cell apoptosis "greater number of male germs cells that undergo programmed cell death" [MGI:csmith]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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