ENSMUSG00000022686


Mus musculus

Features
Gene ID: ENSMUSG00000022686
  
Biological name :B3gnt5
  
Synonyms : B3gnt5 / Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase / Q8BGY6
  
Possible biological names infered from orthology : Q9BYG0 / UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A3
Gene start: 19760208
Gene end: 19772753
  
Corresponding Affymetrix probe sets: 10434291 (MoGene1.0st)   1420993_at (Mouse Genome 430 2.0 Array)   1420994_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078712
Ensembl peptide - ENSMUSP00000112624
Ensembl peptide - ENSMUSP00000113145
Ensembl peptide - ENSMUSP00000126157
NCBI entrez gene - 108105     See in Manteia.
MGI - MGI:2137302
RefSeq - XM_006521706
RefSeq - NM_001159407
RefSeq - NM_001159408
RefSeq - NM_054052
RefSeq Peptide - NP_001152880
RefSeq Peptide - NP_473393
RefSeq Peptide - NP_001152879
swissprot - Q8BGY6
Ensembl - ENSMUSG00000022686
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 b3gnt5bENSDARG00000004396Danio rerio
 Q7T3S5ENSDARG00000018971Danio rerio
 B3GNT5ENSGALG00000032526Gallus gallus
 B3GNT5ENSG00000176597Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm34653 / UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 10 (putative) / A8MXE2* / B3GNT10*ENSMUSG0000010716727
O54905 / B3galt2 / Beta-1,3-galactosyltransferase 2 / O43825*ENSMUSG0000003384927
B3gnt7 / Q8K0J2 / UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 / Q8NFL0*ENSMUSG0000007944526
O54904 / B3galt1 / Beta-1,3-galactosyltransferase 1 / Q9Y5Z6*ENSMUSG0000003478026
B3gnt3 / Q5JCS9 / N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3 / Q9Y2A9* / UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3*ENSMUSG0000003180325
B3gnt9 / Q8VI16 / UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 / Q6UX72*ENSMUSG0000006992025
B3gnt2 / Q9Z222 / N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 / Q9NY97* / UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2*ENSMUSG0000005165024
B3gnt4 / Q1RLK6 / N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4 / Q9C0J1* / UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4*ENSMUSG0000002943124
Q9Z0F0 / B3galt4 / Beta-1,3-galactosyltransferase 4 / O96024*ENSMUSG0000006737023
B3gnt6 / Q3USF0 / Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase / Q6ZMB0* / UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6*ENSMUSG0000007400423
Q9JI67 / B3galt5 / Mus musculus UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 (B3galt5), transcript variant 4, mRNA. / Q9Y2C3* / beta-1,3-galactosyltransferase 5*ENSMUSG0000007489222
B3gnt8 / Q8R3I9 / UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 / Q7Z7M8*ENSMUSG0000005947921
Q920V1 / B3galnt1 / UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 / O75752* / beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)*ENSMUSG0000004330020


Protein motifs (from Interpro)
Interpro ID Name
 IPR002659  Glycosyl transferase, family 31


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0030148 sphingolipid biosynthetic process TAS
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008378 galactosyltransferase activity IEA
 molecular_functionGO:0008457 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0047256 lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity IEA


Pathways (from Reactome)
Pathway description
O-linked glycosylation of mucins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: B3gnt5tm2.1Big/B3gnt5tm2.1Big
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: B3gnt5tm2.1Big/B3gnt5tm2.1Big
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: B3gnt5tm2.1Big/B3gnt5tm2.1Big
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: B3gnt5tm1Big/B3gnt5+
Genetic Background: C57BL/6-B3gnt5tm1Big

Allelic Composition: B3gnt5tm2.1Big/B3gnt5tm2.1Big
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

Allelic Composition: B3gnt5tm2.1Big/B3gnt5+
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: B3gnt5tm1Big/B3gnt5+
Genetic Background: C57BL/6-B3gnt5tm1Big

Allelic Composition: B3gnt5tm2.1Big/B3gnt5+
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: B3gnt5tm1Big/B3gnt5+
Genetic Background: C57BL/6-B3gnt5tm1Big

Allelic Composition: B3gnt5tm2.1Big/B3gnt5tm2.1Big
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

Allelic Composition: B3gnt5tm2.1Big/B3gnt5+
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: B3gnt5tm2.1Big/B3gnt5tm2.1Big
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: B3gnt5tm2.1Big/B3gnt5tm2.1Big
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: B3gnt5tm2.1Big/B3gnt5tm2.1Big
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0008028 pregnancy-related premature death "death occuring before the normal life span of an organism, occuring during pregnancy, parturition or lactation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: B3gnt5tm1Big/B3gnt5+
Genetic Background: C57BL/6-B3gnt5tm1Big

Allelic Composition: B3gnt5tm2.1Big/B3gnt5tm2.1Big
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

Allelic Composition: B3gnt5tm2.1Big/B3gnt5+
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0008234 absent spleen marginal zone "absence of the zone between the red and white pulp of the spleen containing numerous macrophages and lymphocytes, and a rich plexus of sinusoids supplied by white pulp arterioles carrying blood-borne antigens" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: B3gnt5tm2.1Big/B3gnt5tm2.1Big
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0008475 intermingled spleen red and white pulp "no clear demarcation of the spleen red and white pulp tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: B3gnt5tm2.1Big/B3gnt5tm2.1Big
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: B3gnt5tm2.1Big/B3gnt5tm2.1Big
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: B3gnt5tm2.1Big/B3gnt5tm2.1Big
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: B3gnt5tm2.1Big/B3gnt5tm2.1Big
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Prom1tm1(cre/ERT2)Gilb/Prom1+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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