ENSMUSG00000022742


Mus musculus

Features
Gene ID: ENSMUSG00000022742
  
Biological name :Cpox
  
Synonyms : Cpox / Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial / P36552
  
Possible biological names infered from orthology : coproporphyrinogen oxidase / P36551
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: C1.2
Gene start: 58670208
Gene end: 58680391
  
Corresponding Affymetrix probe sets: 10436392 (MoGene1.0st)   1422492_at (Mouse Genome 430 2.0 Array)   1422493_at (Mouse Genome 430 2.0 Array)   1440747_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000055455
NCBI entrez gene - 12892     See in Manteia.
MGI - MGI:104841
RefSeq - NM_007757
RefSeq Peptide - NP_031783
swissprot - P36552
Ensembl - ENSMUSG00000022742
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cpoxENSDARG00000062025Danio rerio
 CPOXENSGALG00000015240Gallus gallus
 CPOXENSG00000080819Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001260  Coproporphyrinogen III oxidase, aerobic
 IPR018375  Coproporphyrinogen III oxidase, conserved site
 IPR036406  Oxygen-dependent coproporphyrinogen III oxidase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006779 porphyrin-containing compound biosynthetic process IEA
 biological_processGO:0006782 protoporphyrinogen IX biosynthetic process IEA
 biological_processGO:0006783 heme biosynthetic process IDA
 biological_processGO:0006813 potassium ion transport TAS
 biological_processGO:0006814 sodium ion transport TAS
 biological_processGO:0010035 response to inorganic substance IEA
 biological_processGO:0010039 response to iron ion IEA
 biological_processGO:0010248 establishment or maintenance of transmembrane electrochemical gradient IEA
 biological_processGO:0010288 response to lead ion IEA
 biological_processGO:0017085 response to insecticide IEA
 biological_processGO:0046685 response to arsenic-containing substance IEA
 biological_processGO:0051597 response to methylmercury IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005758 mitochondrial intermembrane space IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IMP
 molecular_functionGO:0004109 coproporphyrinogen oxidase activity IDA
 molecular_functionGO:0005212 structural constituent of eye lens IMP
 molecular_functionGO:0005391 sodium:potassium-exchanging ATPase activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Heme biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Tcf3tm2Zhu/Tcf3tm2Zhu
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Igdcc3tm1.1Sms/Igdcc3tm1.1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cpoxnct/Cpoxnct,Nctm2BALB/c/Nctm2BALB/c
Genetic Background: involves: BALB/c * MSM

Allelic Composition: Cpoxnct/Cpoxnct
Genetic Background: Not Specified

Allelic Composition: Cpoxnct/Cpoxnct
Genetic Background: involves: BALB/cCrSlc

 MP:0001309 hydropic eye lens fibers "swollen cortical fibers of the eye lens" [J:14285]
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Allelic Composition: Cpoxnct/Cpoxnct
Genetic Background: Not Specified

 MP:0002840 abnormal lens fibers morphology "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cpoxnct/Cpoxnct
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022742 Cpox / P36552 / Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial / P36551* / coproporphyrinogen oxidase*  / complex






 

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