ENSMUSG00000022803


Mus musculus

Features
Gene ID: ENSMUSG00000022803
  
Biological name :Popdc2
  
Synonyms : Popdc2 / Popeye domain-containing protein 2 / Q9ES82
  
Possible biological names infered from orthology : popeye domain containing 2 / Q9HBU9
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B4
Gene start: 38362209
Gene end: 38378216
  
Corresponding Affymetrix probe sets: 10435697 (MoGene1.0st)   1417806_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023494
Ensembl peptide - ENSMUSP00000110387
NCBI entrez gene - 64082     See in Manteia.
MGI - MGI:1930150
RefSeq - XM_006522439
RefSeq - NM_001081984
RefSeq - NM_022318
RefSeq - XM_006522438
RefSeq Peptide - NP_001075453
RefSeq Peptide - NP_071713
swissprot - Q6P3F7
swissprot - Q9ES82
Ensembl - ENSMUSG00000022803
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pla1aENSDARG00000069922Danio rerio
 POPDC2ENSGALG00000014988Gallus gallus
 POPDC2ENSG00000121577Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Popdc3 / Q9ES81 / Popeye domain-containing protein 3 / Q9HBV1* / popeye domain containing 3*ENSMUSG0000001984837
Bves / Q9ES83 / Blood vessel epicardial substance / Q8NE79*ENSMUSG0000007131723


Protein motifs (from Interpro)
Interpro ID Name
 IPR006916  Popeye protein
 IPR014710  RmlC-like jelly roll fold
 IPR018490  Cyclic nucleotide-binding-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002027 regulation of heart rate IMP
 biological_processGO:0042391 regulation of membrane potential IGI
 biological_processGO:0060931 sinoatrial node cell development IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042383 sarcolemma ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0030552 cAMP binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004115 abnormal sinoatrial node morphology "structural anomaly in the small mass of modified cardiac muscle fibers located at the junction of the superior vena cava and the right atruim that is the source of contraction impulses for the heart" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Trp63tm2Brd/Trp63+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004484 altered response of heart to induced stress "change in the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp63tm2Brd/Trp63+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0006142 abnormal sinoatrial node conduction "anomaly in the generation or transfer of electrical impulses that trigger contraction of the atria and ventricles" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Trp63tm2Brd/Trp63+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp63tm2Brd/Trp63+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010637 sinus bradycardia "a type of decreased heart rhythm in which fewer than the normal number of impulses arise from the sinoatrial (SA) node" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Trp63tm2Brd/Trp63+
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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