ENSMUSG00000022811


Mus musculus

Features
Gene ID: ENSMUSG00000022811
  
Biological name :Zfp148
  
Synonyms : Q61624 / Zfp148 / zinc finger protein 148
  
Possible biological names infered from orthology : Q9UQR1 / ZNF148
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B3
Gene start: 33380775
Gene end: 33503903
  
Corresponding Affymetrix probe sets: 10435237 (MoGene1.0st)   1418381_at (Mouse Genome 430 2.0 Array)   1427730_a_at (Mouse Genome 430 2.0 Array)   1436217_at (Mouse Genome 430 2.0 Array)   1449068_at (Mouse Genome 430 2.0 Array)   1449069_at (Mouse Genome 430 2.0 Array)   1455483_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000087106
Ensembl peptide - ENSMUSP00000126338
NCBI entrez gene - 22661     See in Manteia.
MGI - MGI:1332234
RefSeq - XM_017316980
RefSeq - NM_001358569
RefSeq - NM_001358570
RefSeq - NM_011749
RefSeq - XM_006522101
RefSeq - XM_006522102
RefSeq - XM_006522103
RefSeq - XM_006522104
RefSeq - XM_011245888
RefSeq - XM_006522098
RefSeq - XM_006522099
RefSeq - XM_006522100
RefSeq Peptide - NP_001345499
RefSeq Peptide - NP_035879
RefSeq Peptide - NP_001345498
swissprot - Q548L0
swissprot - Q61624
Ensembl - ENSMUSG00000022811
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A0MS83ENSDARG00000055106Danio rerio
 ZNF148ENSGALG00000012049Gallus gallus
 Q9UQR1ENSG00000163848Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99LI5 / Zfp281 / zinc finger protein 281 / Q9Y2X9* / ZNF281*ENSMUSG0000004148330
Q6NZQ6 / Zfp740 / zinc finger protein 740 / Q8NDX6* / ZNF740*ENSMUSG0000004689710
Q8JZL0 / Zfp467 / zinc finger protein 467 / Q7Z7K2* / ZNF467*ENSMUSG000000685519


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007276 gamete generation IMP
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005794 Golgi apparatus ISO
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0043565 sequence-specific DNA binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Ptf1atm1(cre)Cvw/Ptf1atm2Macd
Genetic Background: involves: 129

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2tm1Rohr
Genetic Background: involves: ICR

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Zfp148Gt(XB878)Byg/Zfp148Gt(XB878)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Ube2j1tm1.1(NCOM)Mfgc/Ube2j1tm1.1(NCOM)Mfgc
Genetic Background: C57BL/6N-Ube2j1tm1.1(NCOM)Mfgc/Rbrc

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Zfp148Gt(XB878)Byg/Zfp148Gt(XB878)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Zfp148Gt(XB878)Byg/Zfp148Gt(XB878)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zbtb18tm1Haok/Zbtb18tm1Haok
Genetic Background: involves: 129

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2tm1Rohr
Genetic Background: involves: ICR

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Zfp148Gt(XB878)Byg/Zfp148Gt(XB878)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ube2j1tm1.1(NCOM)Mfgc/Ube2j1tm1.1(NCOM)Mfgc
Genetic Background: C57BL/6N-Ube2j1tm1.1(NCOM)Mfgc/Rbrc

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Ptf1atm1(cre)Cvw/Ptf1atm2Macd
Genetic Background: involves: 129

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2tm1Rohr
Genetic Background: involves: ICR

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zbtb18tm1Haok/Zbtb18tm1Haok
Genetic Background: involves: 129

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Ptf1atm1(cre)Cvw/Ptf1atm2Macd
Genetic Background: involves: 129

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Ptf1atm1(cre)Cvw/Ptf1atm2Macd
Genetic Background: involves: 129

Allelic Composition: Zfp148Gt(XB878)Byg/Zfp148Gt(XB878)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Ptf1atm1(cre)Cvw/Ptf1atm2Macd
Genetic Background: involves: 129

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2tm1Rohr
Genetic Background: involves: ICR

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zfp148Gt(XB878)Byg/Zfp148Gt(XB878)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zbtb18tm1Haok/Zbtb18tm1Haok
Genetic Background: involves: 129

 MP:0010070 decreased serotonin concentration "reduction in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Zbtb18tm1Haok/Zbtb18tm1Haok
Genetic Background: involves: 129

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zbtb18tm1Haok/Zbtb18tm1Haok
Genetic Background: involves: 129

 MP:0010825 abnormal lung saccule morphology "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zfp148Gt(XB878)Byg/Zfp148Gt(XB878)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Zfp148Gt(XB878)Byg/Zfp148Gt(XB878)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Ptf1atm1(cre)Cvw/Ptf1atm2Macd
Genetic Background: involves: 129

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ube2j1tm1.1(NCOM)Mfgc/Ube2j1tm1.1(NCOM)Mfgc
Genetic Background: C57BL/6N-Ube2j1tm1.1(NCOM)Mfgc/Rbrc

 MP:0011239 abnormal skin coloration "a variation in an expected skin color or complexion that may be due to inflammation, pigment defects or other causes" [MGI:llw2]
Show

Allelic Composition: Ube2j1tm1.1(NCOM)Mfgc/Ube2j1tm1.1(NCOM)Mfgc
Genetic Background: C57BL/6N-Ube2j1tm1.1(NCOM)Mfgc/Rbrc

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Ube2j1tm1.1(NCOM)Mfgc/Ube2j1tm1.1(NCOM)Mfgc
Genetic Background: C57BL/6N-Ube2j1tm1.1(NCOM)Mfgc/Rbrc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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